Literature DB >> 17242731

Safety and hypoglycaemic properties of aqueous leaf extract of Ocimum gratissimum in streptozotocin induced diabetic rats.

U G Egesie1, A B Adelaiye, J O Ibu, O J Egesie.   

Abstract

The claim by Nigerian traditional herbal medicine practitioners that Ocimum gratissimum leaves has antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin and graded doses of the aqueous leaf extract were administered orally to the experimentally diabetic rats for 28 days. Administration of the aqueous leaf extract caused a statistically significant reduction in plasma glucose level in streptozotocin induced diabetic rats. The extract appeared nontoxic as evidenced by normal serum levels of AST, ALT, ALP, TPT, ALB and bilirubin. These data appear to agree with claimed hypoglycaemic effects of Ocimum gratissimum.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17242731     DOI： 10.4314/njps.v21i1-2.53971

Source DB:  PubMed          Journal:  Niger J Physiol Sci        ISSN： 0794-859X


  10 in total

Review 1.  The globalization of traditional medicine in northern peru: from shamanism to molecules.

Authors:  Rainer W Bussmann
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-28       Impact factor: 2.629

Review 2.  Antidiabetic Potential of Medicinal Plants and Their Active Components.

Authors:  Bahare Salehi; Athar Ata; Nanjangud V Anil Kumar; Farukh Sharopov; Karina Ramírez-Alarcón; Ana Ruiz-Ortega; Seyed Abdulmajid Ayatollahi; Patrick Valere Tsouh Fokou; Farzad Kobarfard; Zainul Amiruddin Zakaria; Marcello Iriti; Yasaman Taheri; Miquel Martorell; Antoni Sureda; William N Setzer; Alessandra Durazzo; Massimo Lucarini; Antonello Santini; Raffaele Capasso; Elise Adrian Ostrander; Muhammad Iqbal Choudhary; William C Cho; Javad Sharifi-Rad
Journal:  Biomolecules       Date:  2019-09-30

3.  Ocimum gratissimum enhances insulin sensitivity in male Wistar rats with dexamethasone-induced insulin resistance.

Authors:  Shehu-Tijani Toyin Shittu; Taye Jemilat Lasisi; Seyid Alli-Sisse Shittu; Adeyinka Adeyemi; Tolulope James Adeoye; AbdulRasak Akinola Alada
Journal:  J Diabetes Metab Disord       Date:  2021-07-13

4.  [Ethnobotanical study of plants used in the treatment of diabetes in the traditional medicine of Maritime Region, Togo].

Authors:  Gbekley Efui Holaly; Karou Damintoti Simplice; Gnoula Charlemagne; Agbodeka Kodjovi; Anani Kokou; Tchacondo Tchadjobo; Agbonon Amegnona; Batawila Komlan; Simpore Jacques
Journal:  Pan Afr Med J       Date:  2015-04-30

5.  Ocimum gratissimum Ameliorates Gentamicin-Induced Kidney Injury but Decreases Creatinine Clearance Following Sub-Chronic Administration in Rats.

Authors:  Dare J Ogundipe; Rufus O Akomolafe; Abubakar A Sanusi; Christian E Imafidon; Olaoluwa S Olukiran; Ayowole A Oladele
Journal:  J Evid Based Complementary Altern Med       Date:  2017-02-21

Review 6.  A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.).

Authors:  Ositadinma Chinyere Ugbogu; Okezie Emmanuel; Grace Oka Agi; Chibuike Ibe; Celestine Nwabu Ekweogu; Victor Chibueze Ude; Miracle Ebubechi Uche; Rachel Oluchukwu Nnanna; Eziuche Amadike Ugbogu
Journal:  Heliyon       Date:  2021-11-25

7.  Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats.

Authors:  Oe Ofem; Ej Ani; Ae Eno
Journal:  Int J Appl Basic Med Res       Date:  2012-01

8.  Aqueous leaf extract of Ocimum gratissimum improves hematological parameters in alloxan-induced diabetic rats via its antioxidant properties.

Authors:  Shehu-Tijani Toyin Shittu; Wahab A Oyeyemi; Taye J Lasisi; Seyid Alli-Siise Shittu; Temitope T Lawal; Samuel T Olujobi
Journal:  Int J Appl Basic Med Res       Date:  2016 Apr-Jun

9.  Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes.

Authors:  Stanley I R Okoduwa; Isamila A Umar; Dorcas B James; Hajiya M Inuwa
Journal:  Medicines (Basel)       Date:  2017-10-11

10.  Ocimum gratissimum leaf extract may precipitate infertility in male diabetic Wistar rats.

Authors:  Shehu-Tijani Shittu; Seyyid Alli Shittu; Afeez Ayobami Olatunji; Wahab Adekunle Oyeyemi
Journal:  JBRA Assist Reprod       Date:  2019-01-31
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.