Diabetes mellitus and anesthesia.

Diabetes mellitus is an extremely common condition with specific associated comorbidity. Its incidence is rising. Diabetic patients have more perioperative complications than nondiabetic patients. These complications may be related to the presence of organ damage secondary to the diabetes, rather than the defects in carbohydrate metabolism themselves, or to perioperative hyperglycemia. Several new drugs are available for the treatment of diabetes, and these are associated with specific and significant side effects, and varying lengths of action with which the anesthetist should be familiar. Few data are available regarding recommendations for fasting in the presence of these newer drugs. In the postoperative period and during cardiac surgery, hyperglycemia has been shown to be detrimental, and should probably be sought and managed aggressively. The incidence of intraoperative hyperglycemia in noncardiac surgery patients is not as well-defined, nor are the effects of aggressive management.