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Literature DB >> 17240371

Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.

Kazuyuki Takata¹, Yoshihisa Kitamura, Daijiro Yanagisawa, Shigehiro Morikawa, Masahito Morita, Toshiro Inubushi, Daiju Tsuchiya, Saori Chishiro, Mana Saeki, Takashi Taniguchi, Shun Shimohama, Ikuo Tooyama.

Abstract

Immunization with amyloid-beta (Abeta) peptides, a therapeutic approach in Alzheimer's disease (AD), reduces brain Abeta, and microglial Abeta phagocytosis has been proposed as an Abeta-lowering mechanism. We transplanted rat microglia into the rat lateral ventricle just after intra-hippocampal Abeta injection, and then investigated the contribution of exogenous microglia to Abeta clearance. Migration of exogenous microglia from the lateral ventricle to Abeta plaque was detected by magnetic resonance imaging and histochemical analysis, and the clearance of Abeta was increased by transplantation. These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD.

Entities: Disease Gene Species

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Year: 2007 PMID： 17240371 DOI： 10.1016/j.febslet.2007.01.009

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

34 in total

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Review 3. Microglial Aβ receptors in Alzheimer's disease.

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5. Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.

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Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.

1. Therapeutic effects of glatiramer acetate and grafted CD115⁺ monocytes in a mouse model of Alzheimer's disease.

Review 2. Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.

Review 3. Microglial Aβ receptors in Alzheimer's disease.

Review 4. Stem cell-based therapy as a promising approach in Alzheimer's disease: current perspectives on novel treatment.

5. Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.

6. Subventricular zone microglia possess a unique capacity for massive in vitro expansion.

7. Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice.

8. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.

Review 9. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases.

Review 10. Innate immunity in Alzheimer's disease: a complex affair.