OBJECTIVE: The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. STUDY DESIGN: Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. RESULTS: Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined. CONCLUSION: Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.
OBJECTIVE: The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies. STUDY DESIGN:Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu. RESULTS: Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined. CONCLUSION: Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.
Authors: Anniina Färkkilä; Noora Andersson; Ralf Bützow; Arto Leminen; Markku Heikinheimo; Mikko Anttonen; Leila Unkila-Kallio Journal: Cancer Med Date: 2014-03-29 Impact factor: 4.452