OBJECTIVE: This study determines whether pretreatment levels of müllerian inhibiting substance/antimüllerian hormone (MIS/AMH) would reflect ovarian response to exogenous gonadotropin in women with polycystic ovary syndrome (PCOS) and ovulatory controls matched by age and weight. STUDY DESIGN: Case-control study of 20 women with PCOS and 10 normoovulatory women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) at an academic medical center. RESULTS: Baseline serum MIS/AMH levels in PCOS were higher than those of normoovulatory women (P < .001). MIS/AMH levels increased after gonadotropin-releasing hormone (GnRH) agonist pituitary suppression; 0.5 ng/mL in PCOS (P = .12) and 0.7 ng/mL in controls (P < .02). In normoovulatory women, MIS/AMH at baseline, after pituitary suppression, and the interval change after pituitary suppression all correlated closely to the number of mature oocytes retrieved (P < .005). In PCOS, however, levels of MIS/AMH at baseline and after pituitary suppression did not show this correlation, whereas only the interval change correlated with the number of mature oocytes retrieved. CONCLUSION: Baseline MIS/AMH is a good predictor of the ovarian response to COH in normoovulatory women but not in PCOS.
OBJECTIVE: This study determines whether pretreatment levels of müllerian inhibiting substance/antimüllerian hormone (MIS/AMH) would reflect ovarian response to exogenous gonadotropin in women with polycystic ovary syndrome (PCOS) and ovulatory controls matched by age and weight. STUDY DESIGN: Case-control study of 20 women with PCOS and 10 normoovulatory women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) at an academic medical center. RESULTS: Baseline serum MIS/AMH levels in PCOS were higher than those of normoovulatory women (P < .001). MIS/AMH levels increased after gonadotropin-releasing hormone (GnRH) agonist pituitary suppression; 0.5 ng/mL in PCOS (P = .12) and 0.7 ng/mL in controls (P < .02). In normoovulatory women, MIS/AMH at baseline, after pituitary suppression, and the interval change after pituitary suppression all correlated closely to the number of mature oocytes retrieved (P < .005). In PCOS, however, levels of MIS/AMH at baseline and after pituitary suppression did not show this correlation, whereas only the interval change correlated with the number of mature oocytes retrieved. CONCLUSION: Baseline MIS/AMH is a good predictor of the ovarian response to COH in normoovulatory women but not in PCOS.
Authors: Jan R Mellembakken; Sarah L Berga; Mirjam Kilen; Tom G Tanbo; Thomas Abyholm; Peter Fedorcsák Journal: Hum Reprod Date: 2011-06-30 Impact factor: 6.918
Authors: Jori A Leijdekkers; Marinus J C Eijkemans; Theodora C van Tilborg; Simone C Oudshoorn; Ron J T van Golde; Annemieke Hoek; Cornelis B Lambalk; Jan Peter de Bruin; Kathrin Fleischer; Monique H Mochtar; Walter K H Kuchenbecker; Joop S E Laven; Ben Willem J Mol; Helen L Torrance; Frank J M Broekmans Journal: Hum Reprod Date: 2019-06-04 Impact factor: 6.918