| Literature DB >> 17240153 |
Nilo Zanatta1, Sydney H Alves, Helena S Coelho, Deise M Borchhardt, Pablo Machado, Kelen M Flores, Fabio M da Silva, Tatiana B Spader, Jânio M Santurio, Helio G Bonacorso, Marcos A P Martins.
Abstract
The synthesis and characterization of a new series of furan-3-carboxamides, from the aromatization of 4-trichloroacetyl-2,3-dihydrofuran to 3-trichloroacetyl furan followed by nucleophilic displacement of the trichloromethyl group or the corresponding carboxylic acid chloride by nitrogen-containing compounds, is presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including yeast, filamentous fungi, bacteria, and alga. Some of the furan-3-carboxamides exhibited significant in vitro antimicrobial activity. QSAR investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.Entities:
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Year: 2007 PMID： 17240153 DOI： 10.1016/j.bmc.2007.01.003
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641