Literature DB >> 17239596

Antitrypanosomal activity of quaternary naphthalimide derivatives.

Mathias Muth1, Verena Hoerr, Melanie Glaser, Alicia Ponte-Sucre, Heidrun Moll, August Stich, Ulrike Holzgrabe.   

Abstract

Sleeping sickness caused by Trypanosoma brucei gambiense and rhodesiense is fatal if left untreated. Due to the toxicity of drugs currently used and the emerging resistance against these drugs new lead compounds are urgently needed. Within the frame of a broad screening program for drugs with antitrypanosomal activity, some highly potent tertiary and quaternary mono- and bisnaphthalimides being active in the lower micromolar and nanomolar range of concentration have been identified. These compounds are easily available via a two- or three-step microwave-driven synthesis with high yield.

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Year:  2007        PMID： 17239596     DOI： 10.1016/j.bmcl.2006.12.088

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  A Novel Mechanism of Inactivating Antibacterial Nitro Compounds in the Human Pathogen Staphylococcus aureus by Overexpression of a NADH-Dependent Flavin Nitroreductase.

Authors:  Ebaa M El-Hossary; Konrad U Förstner; Patrice François; Damien Baud; Karin Streker; Jacques Schrenzel; Knut Ohlsen; Ulrike Holzgrabe
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

2.  Synthesis and fluorescence study of naphthalimide-coumarin, naphthalimide-luminol conjugates.

Authors:  T Sheshashena Reddy; A Ram Reddy
Journal:  J Fluoresc       Date:  2014-09-03       Impact factor: 2.217

3.  Mode-of-action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus.

Authors:  Thomas M Menzel; Maximilian Tischer; Patrice François; Joachim Nickel; Jacques Schrenzel; Heike Bruhn; Annette Albrecht; Leane Lehmann; Ulrike Holzgrabe; Knut Ohlsen
Journal:  Antimicrob Agents Chemother       Date:  2010-10-11       Impact factor: 5.191

4.  Anti-trypanosomal activities and structural chemical properties of selected compound classes.

Authors:  Alicia Ponte-Sucre; Heike Bruhn; Tanja Schirmeister; Alexander Cecil; Christian R Albert; Christian Buechold; Maximilian Tischer; Susanne Schlesinger; Tim Goebel; Antje Fuß; Daniela Mathein; Benjamin Merget; Christoph A Sotriffer; August Stich; Georg Krohne; Markus Engstler; Gerhard Bringmann; Ulrike Holzgrabe
Journal:  Parasitol Res       Date:  2014-11-23       Impact factor: 2.289

5.  Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity.

Authors:  Georg Hiltensperger; Nina Hecht; Marcel Kaiser; Jens-Christoph Rybak; Alexander Hoerst; Nicole Dannenbauer; Klaus Müller-Buschbaum; Heike Bruhn; Harald Esch; Leane Lehmann; Lorenz Meinel; Ulrike Holzgrabe
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

Review 6.  Novel lead compounds in pre-clinical development against African sleeping sickness.

Authors:  Michael Berninger; Ines Schmidt; Alicia Ponte-Sucre; Ulrike Holzgrabe
Journal:  Medchemcomm       Date:  2017-07-31       Impact factor: 3.597

7.  6-Bromo-2-(diprop-2-ynyl-amino)-1H-benzo[de]isoquinoline-1,3(2H)-dione.

Authors:  Jing-Song Lv; Jun-Lei Wang; Cheng-He Zhou
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-23

8.  Synthesis, FTIR, ¹³C-NMR and temperature-dependent ¹H-NMR characteristics of bis-naphthalimide derivatives.

Authors:  Waldemar Grzesiak; Bogumił Brycki
Journal:  Molecules       Date:  2012-10-22       Impact factor: 4.411

9.  Photochemical Reactivity of Naphthol-Naphthalimide Conjugates and Their Biological Activity.

Authors:  Matija Sambol; Patricia Benčić; Antonija Erben; Marija Matković; Branka Mihaljević; Ivo Piantanida; Marijeta Kralj; Nikola Basarić
Journal:  Molecules       Date:  2021-06-02       Impact factor: 4.411
  9 in total

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