| Literature DB >> 17239593 |
Lluis Ballell1, Robert A Field, Gavin A C Chung, Robert J Young.
Abstract
The multiple parallel synthesis of a series of N,S-bis-alkylated thiopyrazolo[3,4-d]pyrimidines, based on sequential S- then N-alkylation, is reported. These compounds showed significant anti-mycobacterial activity (MICs down to 2mug/ml) and their potential as significant drug-like leads is substantiated through cytotoxicity evaluation and in silico profiling.Entities:
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Year: 2006 PMID： 17239593 DOI： 10.1016/j.bmcl.2006.12.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823