Literature DB >> 17238139

Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis.

Paraskevi Vogiatzi1, Carla Vindigni, Franco Roviello, Alessandra Renieri, Antonio Giordano.   

Abstract

Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy. (c) 2007 Wiley-Liss, Inc.

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Year:  2007        PMID： 17238139     DOI： 10.1002/jcp.20982

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  51 in total

1.  Klotho is silenced through promoter hypermethylation in gastric cancer.

Authors:  Liangjing Wang; Xian Wang; Xiaojia Wang; Pan Jie; Haiqi Lu; Shengjie Zhang; Xiaoying Lin; Emily Ky Lam; Yan Cui; Jun Yu; Hongchuan Jin
Journal:  Am J Cancer Res       Date:  2010-11-10       Impact factor: 6.166

2.  LncRNA-AP001631.9 promotes cell migration in gastric cancer.

Authors:  Hui Cai; Xiaojuan Ye; Bin He; Qiang Li; Yandong Li; Yong Gao
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

3.  CTHRC1 is upregulated by promoter demethylation and transforming growth factor-β1 and may be associated with metastasis in human gastric cancer.

Authors:  Ping Wang; Ying-Chao Wang; Xiao-Yu Chen; Zhi-Yong Shen; Hui Cao; Yan-Jie Zhang; Jian Yu; Jing-De Zhu; You-Yong Lu; Jing-Yuan Fang
Journal:  Cancer Sci       Date:  2012-05-17       Impact factor: 6.716

4.  Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer.

Authors:  Barbara G Schneider; Dun-Fa Peng; M Constanza Camargo; M Blanca Piazuelo; Liviu A Sicinschi; Robertino Mera; Judith Romero-Gallo; Alberto G Delgado; Luis E Bravo; Keith T Wilson; Richard M Peek; Pelayo Correa; Wael El-Rifai
Journal:  Int J Cancer       Date:  2010-12-01       Impact factor: 7.396

5.  Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.

Authors:  Yun Zhang; Hui Cao; Ming Wang; Wen-Yi Zhao; Zhi-Yong Shen; Dan-Ping Shen; Xing-Zhi Ni; Zhi-Yong Wu; Yan-Ying Shen; Yan-Yan Song
Journal:  World J Gastroenterol       Date:  2010-10-07       Impact factor: 5.742

6.  Epigenetic contributions to cancer metastasis.

Authors:  David I Rodenhiser
Journal:  Clin Exp Metastasis       Date:  2008-04-02       Impact factor: 5.150

7.  CHD5 is down-regulated through promoter hypermethylation in gastric cancer.

Authors:  Xian Wang; Kenneth K K Lau; Leo K Y So; Yun Wah Lam
Journal:  J Biomed Sci       Date:  2009-10-19       Impact factor: 8.410

8.  Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer.

Authors:  Y Y Cheng; H Jin; X Liu; J M T Siu; Y P Wong; E K O Ng; J Yu; W-K Leung; J J Y Sung; F K L Chan
Journal:  Br J Cancer       Date:  2008-11-04       Impact factor: 7.640

9.  Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer.

Authors:  Yang Lu; Ping Lu; Zhi Zhu; Huimian Xu; Xike Zhu
Journal:  J Exp Clin Cancer Res       Date:  2009-09-09

10.  A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.

Authors:  Hiroaki Mita; Minoru Toyota; Fumio Aoki; Hirofumi Akashi; Reo Maruyama; Yasushi Sasaki; Hiromu Suzuki; Masashi Idogawa; Lisa Kashima; Kazuyoshi Yanagihara; Masahiro Fujita; Masao Hosokawa; Masanobu Kusano; Sorin Vasile Sabau; Haruyuki Tatsumi; Kohzoh Imai; Yasuhisa Shinomura; Takashi Tokino
Journal:  BMC Cancer       Date:  2009-06-23       Impact factor: 4.430
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