Kin F Chin1, R Kallam, Colm O'Boyle, John MacFie. 1. Department of General Surgery, Combined Gastroenterology Unit, Scarborough Hospital, Scarborough, North Yorkshire, United Kingdom.
Abstract
PURPOSE: The purpose of this study was to investigate the association of bacterial translocation with long-term disease-specific and disease-free survival in colorectal cancer patients. METHODS: This was a prospective cohort study in which 128 and 30 colorectal cancer patients undergoing curative and palliative resections, respectively, were recruited between 1992 and 1997. Samples of mesenteric lymph nodes were harvested for culture before administration of prophylactic antibiotics. Median follow-up for patients without cancer death was 103 (range, 72-147) months. This cohort of patients was internally validated by Dukes staging. RESULTS: The cumulative disease-specific survival (time to death) and disease-free survival (time to recurrence) for all patients at five years of follow-up was 55 percent (standard error [SE], 4.4 percent) and 65 percent (SE, 4.8 percent), respectively. Bacteria were isolated from the mesenteric nodes of 23 (15 percent) patients. There was no association between bacterial translocation and nodal metastases, bowel obstruction, and septic complications. Patients with confirmed bacterial translocation had a worse disease-specific survival (n=158, 5-year survivorship estimates+/-SE, 38 percent+/-12 percent vs. 58 percent+/-4.7 percent; P < 0.01) and disease-free survival (n=128, 5-year survivorship estimates+/-SE, 46 percent+/-14 percent vs. 66 percent+/-5 percent; P = 0.004) than those without. Using multivariate Cox regression analysis, bacterial translocation was a predictor of disease-specific survival (P = 0.011) and disease-free survival (P = 0.02) independent of other pathologic prognostic indicators. CONCLUSION: Colorectal cancer patients with bacterial translocation in the mesenteric lymph nodes have a worse outcome.
PURPOSE: The purpose of this study was to investigate the association of bacterial translocation with long-term disease-specific and disease-free survival in colorectal cancerpatients. METHODS: This was a prospective cohort study in which 128 and 30 colorectal cancerpatients undergoing curative and palliative resections, respectively, were recruited between 1992 and 1997. Samples of mesenteric lymph nodes were harvested for culture before administration of prophylactic antibiotics. Median follow-up for patients without cancer death was 103 (range, 72-147) months. This cohort of patients was internally validated by Dukes staging. RESULTS: The cumulative disease-specific survival (time to death) and disease-free survival (time to recurrence) for all patients at five years of follow-up was 55 percent (standard error [SE], 4.4 percent) and 65 percent (SE, 4.8 percent), respectively. Bacteria were isolated from the mesenteric nodes of 23 (15 percent) patients. There was no association between bacterial translocation and nodal metastases, bowel obstruction, and septic complications. Patients with confirmed bacterial translocation had a worse disease-specific survival (n=158, 5-year survivorship estimates+/-SE, 38 percent+/-12 percent vs. 58 percent+/-4.7 percent; P < 0.01) and disease-free survival (n=128, 5-year survivorship estimates+/-SE, 46 percent+/-14 percent vs. 66 percent+/-5 percent; P = 0.004) than those without. Using multivariate Cox regression analysis, bacterial translocation was a predictor of disease-specific survival (P = 0.011) and disease-free survival (P = 0.02) independent of other pathologic prognostic indicators. CONCLUSION:Colorectal cancerpatients with bacterial translocation in the mesenteric lymph nodes have a worse outcome.
Authors: Nuray Gül; Simran Grewal; Marijn Bögels; Gerben J van der Bij; Malika M A Koppes; Steven J Oosterling; Donna M Fluitsma; Kees A Hoeben; Robert H J Beelen; Marjolein van Egmond Journal: Oncoimmunology Date: 2012-12-01 Impact factor: 8.110