| Literature DB >> 1723758 |
W X Tang1, P L Li, W Y Zhang, S B Li.
Abstract
Efficacy of the conjugate anti-AFP-F(ab)'2 with adriamycin, anti-AFP-F(ab)'2-adr, against transplantable tumors was studied in mice. The results showed that LD50 of anti-AFP-F(ab)'2-adr in mice was 7.43 mg/kg and that anti-AFP-F(ab)'2-adr in a dose of 1/10-1/5 LD50 could inhibit the growth of transplanted hepatocellular carcinoma. In addition, anti-AFP-F(ab)'2-adr with local application of AFP could markedly inhibit the growth of transplanted Ehrlich ascites cancer. From the above it is suggested that anti-AFP-F(ab)'2-adr can be used to treat hepatic carcinoma with satisfactory results.Entities:
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Year: 1991 PMID： 1723758 DOI： 10.1007/bf02888127
Source DB: PubMed Journal: J Tongji Med Univ ISSN： 0257-716X