OBJECTIVE: To replicate the association of frizzled-related protein (FRZB) non-synonymous polymorphisms with osteoarthritis (OA) susceptibility. METHODS: Three groups of Spanish patients with OA were included: with total joint replacement due to primary OA in the hip (n = 310), or the knee (n = 277), or with hand OA (n = 242). Controls were more than 55 years old and did not show OA (n = 294). SNPs rs288326 (R200W) and rs7775 (R324G) were genotyped. RESULTS: There were no significant differences in allele frequencies between controls and each of the three groups of OA patients. However, allele G of the R324G SNP showed a trend to be more frequent in patients with a clinical OA syndrome at multiple joints (p = 0.07), specifically in women of the total hip replacement group (8.3% in patients without other affected joints, 13.1% with one, 15.9% with two and 24.1% with more than two additional joints, p for trend = 0.008). CONCLUSIONS: No direct replication of previous OA association findings was obtained but the results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip in women. This phenotype could reconcile previous studies that showed association either with generalised OA or with hip OA in women.
OBJECTIVE: To replicate the association of frizzled-related protein (FRZB) non-synonymous polymorphisms with osteoarthritis (OA) susceptibility. METHODS: Three groups of Spanish patients with OA were included: with total joint replacement due to primary OA in the hip (n = 310), or the knee (n = 277), or with hand OA (n = 242). Controls were more than 55 years old and did not show OA (n = 294). SNPs rs288326 (R200W) and rs7775 (R324G) were genotyped. RESULTS: There were no significant differences in allele frequencies between controls and each of the three groups of OA patients. However, allele G of the R324G SNP showed a trend to be more frequent in patients with a clinical OA syndrome at multiple joints (p = 0.07), specifically in women of the total hip replacement group (8.3% in patients without other affected joints, 13.1% with one, 15.9% with two and 24.1% with more than two additional joints, p for trend = 0.008). CONCLUSIONS: No direct replication of previous OA association findings was obtained but the results suggest that the R324G SNP of the FRZB gene may have an effect in OA development in multiple joints, with a specific severe involvement of the hip in women. This phenotype could reconcile previous studies that showed association either with generalised OA or with hip OA in women.
Authors: I Meulenbelt; M Kloppenburg; H M Kroon; J J Houwing-Duistermaat; P Garnero; M-P Hellio-Le Graverand; J DeGroot; P E Slagboom Journal: Osteoarthritis Cartilage Date: 2006-10-17 Impact factor: 6.576
Authors: N E Lane; K Lian; M C Nevitt; J M Zmuda; L Lui; J Li; J Wang; M Fontecha; N Umblas; M Rosenbach; P de Leon; M Corr Journal: Arthritis Rheum Date: 2006-04
Authors: Peter V N Bodine; Weiguang Zhao; Yogendra P Kharode; Frederick J Bex; Andre-Jean Lambert; Mary Beth Goad; Tripti Gaur; Gary S Stein; Jane B Lian; Barry S Komm Journal: Mol Endocrinol Date: 2004-02-19
Authors: John Loughlin; Barbara Dowling; Kay Chapman; Lucy Marcelline; Zehra Mustafa; Lorraine Southam; Athena Ferreira; Cathleen Ciesielski; Dennis A Carson; Maripat Corr Journal: Proc Natl Acad Sci U S A Date: 2004-06-21 Impact factor: 11.205
Authors: Julio Rodriguez-Lopez; Manuel Pombo-Suarez; Myriam Liz; Juan J Gomez-Reino; Antonio Gonzalez Journal: Arthritis Res Ther Date: 2006-03-10 Impact factor: 5.156
Authors: Julie C Baker-Lepain; John A Lynch; Neeta Parimi; Charles E McCulloch; Michael C Nevitt; Maripat Corr; Nancy E Lane Journal: Arthritis Rheum Date: 2012-05
Authors: Evangelos Evangelou; Kay Chapman; Ingrid Meulenbelt; Fotini B Karassa; John Loughlin; Andrew Carr; Michael Doherty; Sally Doherty; Juan J Gómez-Reino; Antonio Gonzalez; Bjarni V Halldorsson; Valdimar B Hauksson; Albert Hofman; Deborah J Hart; Shiro Ikegawa; Thorvaldur Ingvarsson; Qing Jiang; Ingileif Jonsdottir; Helgi Jonsson; Hanneke J M Kerkhof; Margreet Kloppenburg; Nancy E Lane; Jia Li; Rik J Lories; Joyce B J van Meurs; Annu Näkki; Michael C Nevitt; Julio Rodriguez-Lopez; Dongquan Shi; P Eline Slagboom; Kari Stefansson; Aspasia Tsezou; Gillian A Wallis; Christopher M Watson; Tim D Spector; Andre G Uitterlinden; Ana M Valdes; John P A Ioannidis Journal: Arthritis Rheum Date: 2009-06