PURPOSE: To determine the frequency of acute and chronic adverse effects in patients with scleroderma who receive radiotherapy for treatment of cancer. METHODS AND MATERIALS: Records were reviewed of 20 patients with scleroderma who received radiotherapy. Acute and chronic toxic effects attributable to radiotherapy were analyzed, and freedom from radiation-related toxicity was calculated. RESULTS: Of the 20 patients, 15 had acute toxic effects, with Grade 3 or higher toxicity for 3 patients. Seven patients had self-limited Grade 1 or 2 radiation dermatitis, and no patient had Grade 3 or higher radiation dermatitis. Thirteen patients had chronic toxic effects, with Grade 3 or higher chronic toxicity for 3 patients. The median estimated time to any grade chronic toxicity was 0.4 years, and the median estimated time to Grade 3 or higher chronic toxicity has not been reached. CONCLUSIONS: The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated.
PURPOSE: To determine the frequency of acute and chronic adverse effects in patients with scleroderma who receive radiotherapy for treatment of cancer. METHODS AND MATERIALS: Records were reviewed of 20 patients with scleroderma who received radiotherapy. Acute and chronic toxic effects attributable to radiotherapy were analyzed, and freedom from radiation-related toxicity was calculated. RESULTS: Of the 20 patients, 15 had acute toxic effects, with Grade 3 or higher toxicity for 3 patients. Seven patients had self-limited Grade 1 or 2 radiation dermatitis, and no patient had Grade 3 or higher radiation dermatitis. Thirteen patients had chronic toxic effects, with Grade 3 or higher chronic toxicity for 3 patients. The median estimated time to any grade chronic toxicity was 0.4 years, and the median estimated time to Grade 3 or higher chronic toxicity has not been reached. CONCLUSIONS: The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated.
Authors: Dhaval J Shah; Ram Hirpara; Corrie L Poelman; Adrianne Woods; Laura K Hummers; Fredrick M Wigley; Jean L Wright; Arti Parekh; Virginia D Steen; Robyn T Domsic; Ami A Shah Journal: Arthritis Care Res (Hoboken) Date: 2018-10 Impact factor: 4.794
Authors: Jeffrey M Straub; Jacob New; Chase D Hamilton; Chris Lominska; Yelizaveta Shnayder; Sufi M Thomas Journal: J Cancer Res Clin Oncol Date: 2015-04-25 Impact factor: 4.553
Authors: George Kyrgias; Kiki Theodorou; Anna Zygogianni; Konstantinos Tsanadis; Stefanos Zervoudis; John Tzitzikas; Michael Koukourakis Journal: Breast Cancer (Dove Med Press) Date: 2012-01-24
Authors: Ajaykumar B Patel; Christopher L Hallemeier; Ivy A Petersen; Ashley W Jensen; Thomas G Osborn; Robert C Miller Journal: Radiat Oncol Date: 2012-02-16 Impact factor: 3.481
Authors: Christina A Dilaveri; Nicole P Sandhu; Lonzetta Neal; Michelle A Neben-Wittich; Tina J Hieken; Maire Brid Mac Bride; Dietlind L Wahner-Roedler; Karthik Ghosh Journal: Int J Womens Health Date: 2014-11-19