PURPOSE: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. METHODS AND MATERIALS: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node (LN) metastasis. RESULTS: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 +/- 13.5 mm proximally (<30 mm in 32 of 34 cases) and 10.6 +/- 8.1 mm distally (<30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 +/- 7.2 mm proximally (<30 mm in 29 of 29 cases) and 18.3 +/- 16.3 mm distally (<30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (p = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma. CONCLUSIONS: The extent of microscopic spread within esophagus (recommended CTV margin) was <30 mm in about 94% of cases of esophageal cancer, except for distal microscopic spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases.
PURPOSE: To clarify the radiotherapy clinical target volume (CTV) margin needed for esophageal squamous-cell carcinoma (SCC) and gastroesophageal junction (GEJ) adenocarcinoma. METHODS AND MATERIALS: Surgical specimens of esophageal SCC (n = 34) and GEJ adenocarcinoma (n = 32) were prospectively collected and analyzed for microscopic spread along the esophagus and GEJ both proximally and distally from gross tumor and for lymph node (LN) metastasis. RESULTS: For SCC, the mean microscopic spread beyond the gross tumor was 10.5 +/- 13.5 mm proximally (<30 mm in 32 of 34 cases) and 10.6 +/- 8.1 mm distally (<30 mm in 33 of 34 cases). For GEJ adenocarcinoma, the spread was 10.3 +/- 7.2 mm proximally (<30 mm in 29 of 29 cases) and 18.3 +/- 16.3 mm distally (<30 mm in 27 of 32 cases). The extent of microscopic spread of cancer was significantly associated with pathologic T stage (p = 0.012). LN metastases were observed in 12 (35%) of 34 patients with middle and lower esophageal SCC and 15 (47%) of 32 patients with GEJ adenocarcinoma. CONCLUSIONS: The extent of microscopic spread within esophagus (recommended CTV margin) was <30 mm in about 94% of cases of esophageal cancer, except for distal microscopic spread in GEJ adenocarcinoma, in which 50 mm was needed to cover about 94% of cases.
Authors: Abraham J Wu; Walter R Bosch; Daniel T Chang; Theodore S Hong; Salma K Jabbour; Lawrence R Kleinberg; Harvey J Mamon; Charles R Thomas; Karyn A Goodman Journal: Int J Radiat Oncol Biol Phys Date: 2015-04-02 Impact factor: 7.038
Authors: Karim Sillah; Luke R Williams; Hans-Ulrich Laasch; Azeem Saleem; Gillian Watkins; Susan A Pritchard; Patricia M Price; Catharine M West; Ian M Welch Journal: World J Gastrointest Oncol Date: 2010-04-15
Authors: Peter S N van Rossum; Richard van Hillegersberg; Frederiek M Lever; Irene M Lips; Astrid L H M W van Lier; Gert J Meijer; Maarten S van Leeuwen; Marco van Vulpen; Jelle P Ruurda Journal: Eur Radiol Date: 2013-02-13 Impact factor: 5.315
Authors: Francine E M Voncken; Erik Vegt; Johanna W van Sandick; Jolanda M van Dieren; Cecile Grootscholten; Annemarieke Bartels-Rutten; Steven L Takken; Jan-Jakob Sonke; Jeroen B van de Kamer; Berthe M P Aleman Journal: Strahlenther Onkol Date: 2021-04-07 Impact factor: 3.621