| Literature DB >> 17236765 |
Stephen C McKeown1, Adrian Hall, Richard Blunt, Susan H Brown, Iain P Chessell, Anita Chowdhury, Gerard M P Giblin, Mark P Healy, Matthew R Johnson, Olivier Lorthioir, Anton D Michel, Alan Naylor, Xiao Lewell, Shilina Roman, Stephen P Watson, Wendy J Winchester, Richard J Wilson.
Abstract
A high-throughput screen targeting the EP(1) receptor identified non-acidic glycine sulfonamide derivative 2a with a pK(i) of 6.2. Analogue synthesis allowed a thorough investigation of the structure-activity relationship (SAR) and led to a 100-fold increase in recombinant potency.Entities:
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Year: 2006 PMID： 17236765 DOI： 10.1016/j.bmcl.2006.12.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823