| Literature DB >> 17236763 |
Brent W McCleland1, Roderick S Davis, Michael R Palovich, Katherine L Widdowson, Michelle L Werner, Miriam Burman, James J Foley, Dulcie B Schmidt, Henry M Sarau, Martin Rogers, Kevin L Salyers, Peter D Gorycki, Theresa J Roethke, Gary J Stelman, Leonard M Azzarano, Keith W Ward, Jakob Busch-Petersen.
Abstract
N,N'-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N'-diarylurea series. As was the case in the N,N'-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies.Entities:
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Year: 2006 PMID： 17236763 DOI： 10.1016/j.bmcl.2006.12.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823