Literature DB >> 1723648

Production and characterization of new monoclonal antibodies to human osteoclasts.

P N Nelson1, J A Pringle, T J Chambers.   

Abstract

Two monoclonal antibodies raised against human osteoclastoma were found to show antiosteoclastic activity on frozen sections of tumor. Immunoreactivity was localized on the membrane surface. These antibodies exhibited no activity against tissue macrophages and human visceral tissue except kidney, where they stained tubules but not glomeruli. In addition, no activity was observed against rabbit or rat osteoclasts, suggesting that they might react with unique epitopes on human osteoclasts.

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Year:  1991        PMID： 1723648     DOI： 10.1007/bf02556253

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  19 in total

Review 1.  Bone cell biology: the regulation of development, structure, and function in the skeleton.

Authors:  S C Marks; S N Popoff
Journal:  Am J Anat       Date:  1988-09

2.  Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

Authors:  G C Nicholson; J M Moseley; P M Sexton; F A Mendelsohn; T J Martin
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

3.  Calcitonin receptors of kidney and bone.

Authors:  S J Marx; C J Woodward; G D Aurbach
Journal:  Science       Date:  1972-12-01       Impact factor: 47.728

4.  Immunohistochemical characterization of osteoclasts and osteoclast-like cells with monoclonal antibody MB1 on paraffin-embedded tissues.

Authors:  M Chilosi; E Gilioli; M Lestani; F Menestrina; L Fiore-Donati
Journal:  J Pathol       Date:  1988-11       Impact factor: 7.996

Review 5.  The origin of osteoclasts: evidence, clinical implications and investigative challenges of an extra-skeletal source.

Authors:  S C Marks
Journal:  J Oral Pathol       Date:  1983-08

6.  Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.

Authors:  M A Horton; D Lewis; K McNulty; J A Pringle; T J Chambers
Journal:  Cancer Res       Date:  1985-11       Impact factor: 12.701

7.  Human osteoclast-specific antigens are expressed by osteoclasts in a wide range of non-human species.

Authors:  M A Horton; T J Chambers
Journal:  Br J Exp Pathol       Date:  1986-02

8.  Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas.

Authors:  H Stein; A Bonk; G Tolksdorf; K Lennert; H Rodt; J Gerdes
Journal:  J Histochem Cytochem       Date:  1980-08       Impact factor: 2.479

9.  Cell surface characterization of the human osteoclast: phenotypic relationship to other bone marrow-derived cell types.

Authors:  M A Horton; E F Rimmer; D Lewis; J A Pringle; K Fuller; T J Chambers
Journal:  J Pathol       Date:  1984-12       Impact factor: 7.996

10.  Identification of osteoclast-specific monoclonal antibodies.

Authors:  M J Oursler; L V Bell; B Clevinger; P Osdoby
Journal:  J Cell Biol       Date:  1985-05       Impact factor: 10.539
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  2 in total

Review 1.  Acid phosphatases.

Authors:  H Bull; P G Murray; D Thomas; A M Fraser; P N Nelson
Journal:  Mol Pathol       Date:  2002-04

2.  A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices.

Authors:  K Hata; T Kukita; A Akamine; A Kukita; K Kurisu; T Iijima
Journal:  Histochemistry       Date:  1994-06
  2 in total

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