| Literature DB >> 17235565 |
Tomonori Sasahira1, Tadaaki Kirita, Ujjal K Bhawal, Masayuki Ikeda, Akira Nagasawa, Kazuhiko Yamamoto, Hiroki Kuniyasu.
Abstract
The receptor for advanced glycation end products (RAGE) is associated with cancer progression in several human cancers. In this study, we examined the roles of RAGE in the angiogenesis of oral squamous cell carcinoma (OSCC). RAGE concentration was examined in 20 OSCC tumors by enzyme-linked immunosorbent assay (ELISA). The microvessel density (MVD) and lymph vessel density (LVD) were examined by immunostaining. Concentrations of vascular endothelial growth factor (VEGF) and VEGF-C were examined in tumor tissues by ELISA. Tumoral RAGE concentration was associated with higher tumor MVD (P = 0.0123) and tumor VEGF concentration (P = 0.0344), but not with LVD and VEGF-C concentration. Treatment with RAGE ligand, high-mobility group box (HMGB)-1 increased the secretion of VEGF but not that of VEGF-C in human OSCC cell lines, HSC-3 and HSC-4. The effect of HMGB-1 was abrogated by RAGE down-regulation by antisense S-oligodeoxynucleic acid. These results suggest that RAGE expression is closely associated to angiogenesis in OSCC.Entities:
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Year: 2007 PMID： 17235565 DOI： 10.1007/s00428-006-0359-2
Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064