Literature DB >> 17234915

Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.

Michelangelo Cordenonsi1, Marco Montagner, Maddalena Adorno, Luca Zacchigna, Graziano Martello, Anant Mamidi, Sandra Soligo, Sirio Dupont, Stefano Piccolo.   

Abstract

During development and tissue homeostasis, cells must integrate different signals. We investigated how cell behavior is controlled by the combined activity of transforming growth factor-beta (TGF-beta) and receptor tyrosine kinase (RTK) signaling, whose integration mechanism is unknown. We find that RTK/Ras/MAPK (mitogen-activated protein kinase) activity induces p53 N-terminal phosphorylation, enabling the interaction of p53 with the TGF-beta-activated Smads. This mechanism confines mesoderm specification in Xenopus embryos and promotes TGF-beta cytostasis in human cells. These data indicate a mechanism to allow extracellular cues to specify the TGF-beta gene-expression program.

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Year:  2007        PMID： 17234915     DOI： 10.1126/science.1135961

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  88 in total

Review 1.  TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.

Authors:  Rohan Samarakoon; Jessica M Overstreet; Stephen P Higgins; Paul J Higgins
Journal:  Cell Tissue Res       Date:  2011-06-04       Impact factor: 5.249

2.  RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines.

Authors:  Feng-Xian Zhai; Xiang-Fu Liu; Rui-Fang Fan; Zi-Jie Long; Zhi-Gang Fang; Ying Lu; Yong-Jiang Zheng; Dong-Jun Lin
Journal:  J Cancer Res Clin Oncol       Date:  2011-12-18       Impact factor: 4.553

Review 3.  Posttranslational modification of p53: cooperative integrators of function.

Authors:  David W Meek; Carl W Anderson
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-10-28       Impact factor: 10.005

4.  Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin.

Authors:  Kun Zhang; Sandeep K Rajput; Kyung-Bon Lee; Dongliang Wang; Juncheng Huang; Joseph K Folger; Jason G Knott; Jiuzhen Zhang; George W Smith
Journal:  Biol Reprod       Date:  2015-08-19       Impact factor: 4.285

Review 5.  TGFbeta superfamily signaling: notes from the desert.

Authors:  Richard W Padgett; Michael Reiss
Journal:  Development       Date:  2007-10       Impact factor: 6.868

6.  Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer.

Authors:  Yi Zhong; Anne Macgregor-Das; Tyler Saunders; Martin C Whittle; Alvin Makohon-Moore; Zachary A Kohutek; Justin Poling; Brian T Herbst; Breanna M Javier; Leslie Cope; Steven D Leach; Sunil R Hingorani; Christine A Iacobuzio-Donahue
Journal:  Clin Cancer Res       Date:  2016-09-16       Impact factor: 12.531

Review 7.  The microRNA networks of TGFβ signaling in cancer.

Authors:  V P Sivadas; S Kannan
Journal:  Tumour Biol       Date:  2013-12-10

8.  Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.

Authors:  Lei Ji; Jinjin Xu; Jian Liu; Ali Amjad; Kun Zhang; Qingwu Liu; Lei Zhou; Jianru Xiao; Xiaotao Li
Journal:  J Biol Chem       Date:  2015-03-12       Impact factor: 5.157

9.  Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II.

Authors:  Eyal Kalo; Yosef Buganim; Keren E Shapira; Hilla Besserglick; Naomi Goldfinger; Lilach Weisz; Perry Stambolsky; Yoav I Henis; Varda Rotter
Journal:  Mol Cell Biol       Date:  2007-09-17       Impact factor: 4.272

Review 10.  TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.

Authors:  Rohan Samarakoon; Jessica M Overstreet; Paul J Higgins
Journal:  Cell Signal       Date:  2012-10-11       Impact factor: 4.315
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