Literature DB >> 17234340

Only high concentrations of ethanol affect GABAA receptors of rat cerebellum granule cells in culture.

S Casagrande1, A Cupello, F Pellistri, M Robello.   

Abstract

In the experiments described in the present report, we evaluated the effects of ethanol on the activity of GABAA receptors of cerebellar granule cells in culture. Only very high ethanol concentrations (100-300 mM) showed a clear and significant stimulatory effect on the activity of such receptors. This result was unexpected. In fact, previous reports from other groups would have suggested high ethanol sensitivity of at least one population of GABAA receptors expressed by granule cells.

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Year:  2006        PMID: 17234340     DOI: 10.1016/j.neulet.2006.12.024

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  11 in total

Review 1.  Stress, ethanol, and neuroactive steroids.

Authors:  Giovanni Biggio; Alessandra Concas; Paolo Follesa; Enrico Sanna; Mariangela Serra
Journal:  Pharmacol Ther       Date:  2007-05-08       Impact factor: 12.310

Review 2.  Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results.

Authors:  Cecilia M Borghese; R Adron Harris
Journal:  Alcohol       Date:  2007-05-23       Impact factor: 2.405

3.  Effect of chronic administration of ethanol on the regulation of the delta-subunit of GABA(A) receptors in the rat brain.

Authors:  C R Marutha Ravindran; Ashok K Mehta; Maharaj K Ticku
Journal:  Brain Res       Date:  2007-08-16       Impact factor: 3.252

4.  Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol.

Authors:  Marcia J Ramaker; Matthew M Ford; Andrea M Fretwell; Deborah A Finn
Journal:  Alcohol Clin Exp Res       Date:  2011-06-07       Impact factor: 3.455

5.  Nonspecific interaction of prefibrillar amyloid aggregates with glutamatergic receptors results in Ca2+ increase in primary neuronal cells.

Authors:  Francesca Pellistri; Monica Bucciantini; Annalisa Relini; Daniele Nosi; Alessandra Gliozzi; Mauro Robello; Massimo Stefani
Journal:  J Biol Chem       Date:  2008-08-01       Impact factor: 5.157

Review 6.  The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.

Authors:  Sandeep Kumar; Patrizia Porcu; David F Werner; Douglas B Matthews; Jaime L Diaz-Granados; Rebecca S Helfand; A Leslie Morrow
Journal:  Psychopharmacology (Berl)       Date:  2009-05-20       Impact factor: 4.530

Review 7.  GABAA receptor subtypes: the "one glass of wine" receptors.

Authors:  Richard W Olsen; Harry J Hanchar; Pratap Meera; Martin Wallner
Journal:  Alcohol       Date:  2007-05       Impact factor: 2.405

Review 8.  Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition.

Authors:  Vijayalakshmi Santhakumar; Martin Wallner; Thomas S Otis
Journal:  Alcohol       Date:  2007-05       Impact factor: 2.405

9.  Low concentrations of ethanol do not affect radioligand binding to the delta-subunit-containing GABAA receptors in the rat brain.

Authors:  Ashok K Mehta; C R Marutha Ravindran; Maharaj K Ticku
Journal:  Brain Res       Date:  2007-07-26       Impact factor: 3.252

Review 10.  Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies.

Authors:  Paolo Botta; Richard A Radcliffe; Mario Carta; Manuel Mameli; Erin Daly; Kirsten L Floyd; Richard A Deitrich; C Fernando Valenzuela
Journal:  Alcohol       Date:  2007-05-23       Impact factor: 2.405

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