Literature DB >> 17234146

Neutrophils as potential therapeutic targets in sepsis.

K Alun Brown1, David F Treacher.   

Abstract

Neutrophils are important, expeditious front-line "soldiers" in fighting against bacterial infection. In sepsis, the overwhelming immune response to bacterial infection precipitates systemic inflammation and organ dysfunction. Neutrophils release many lysis-inducing factors and cause local tissue damage, and neutrophils themselves became a target in controlling sepsis.

Entities:  

Mesh：

Year:  2006        PMID： 17234146

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  9 in total

1.  Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.

Authors:  Ruonan Xu; Fang Lin; Chunmei Bao; Huihuang Huang; Chengcheng Ji; Siyu Wang; Lei Jin; Lijian Sun; Ke Li; Zheng Zhang; Fu-Sheng Wang
Journal:  Cell Mol Immunol       Date:  2015-03-02       Impact factor: 11.530

2.  Long-Term Microgliosis Driven by Acute Systemic Inflammation.

Authors:  Alissa Trzeciak; Yelena V Lerman; Tae-Hyoun Kim; Ma Rie Kim; Nguyen Mai; Marc W Halterman; Minsoo Kim
Journal:  J Immunol       Date:  2019-10-16       Impact factor: 5.422

3.  PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.

Authors:  Jan M Herter; Andreas Margraf; Stephanie Volmering; Benedito Eduardo Correia; J Michael Bradshaw; Angelina Bisconte; Ronald J Hill; Claire L Langrish; Clifford A Lowell; Alexander Zarbock
Journal:  Br J Pharmacol       Date:  2017-12-22       Impact factor: 8.739

4.  Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan.

Authors:  Camila Fernanda Estevão-Silva; Raquel Kummer; Fernanda Carolina Fachini-Queiroz; Renata Grespan; Gessilda Alcântara Nogueira de Melo; Silmara Baroni; Roberto Kenji Nakamura Cuman; Ciomar Aparecida Bersani-Amado
Journal:  J Nat Med       Date:  2014-05-01       Impact factor: 2.343

5.  Experimental Sepsis Severity Score Associated to Mortality and Bacterial Spreading is Related to Bacterial Load and Inflammatory Profile of Different Tissues.

Authors:  Muryel Carvalho Gonçalves; Verônica Vargas Horewicz; Débora Denardin Lückemeyer; Arthur Silveira Prudente; Jamil Assreuy
Journal:  Inflammation       Date:  2017-10       Impact factor: 4.092

6.  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice.

Authors:  Yuki Takaoka; Shigeru Goto; Toshiaki Nakano; Hui-Peng Tseng; Shih-Ming Yang; Seiji Kawamoto; Kazuhisa Ono; Chao-Long Chen
Journal:  Sci Rep       Date:  2014-06-06       Impact factor: 4.379

7.  Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality.

Authors:  Alissa Trzeciak; Raj Kumar Mongre; Ma Rie Kim; Kihong Lim; Rafael A Madero; Christopher N Parkhurst; Anthony P Pietropaoli; Minsoo Kim
Journal:  Front Immunol       Date:  2022-08-02       Impact factor: 8.786

Review 8.  Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology.

Authors:  Marta Martín-Fernández; Álvaro Tamayo-Velasco; Rocío Aller; Hugo Gonzalo-Benito; Pedro Martínez-Paz; Eduardo Tamayo
Journal:  Int J Mol Sci       Date:  2021-06-10       Impact factor: 5.923

9.  Circulating neutrophil counts and mortality in septic shock.

Authors:  Jesús F Bermejo-Martín; Eduardo Tamayo; Gema Ruiz; David Andaluz-Ojeda; Rubén Herrán-Monge; Arturo Muriel-Bombín; Maria Fe Muñoz; María Heredia-Rodríguez; Rafael Citores; José Gómez-Herreras; Jesús Blanco
Journal:  Crit Care       Date:  2014-02-14       Impact factor: 9.097
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.