| Literature DB >> 17234129 |
Cornelia M Ulrich1, Jeannette Bigler, John D Potter.
Abstract
It was shown that NSAIDs, such as aspirin or Celebrex, are effective cancer preventive agents when taken regularly. However, the long-term use of NSAIDs, the cyclooxygenase (COX) inhibitors, may have significant adverse effects - primarily on the gastrointestinal (inhibiting COX-1) and cardiovascular (inhibiting COX-2) systems. Genetic analysis of enzymes (including COX) involved in the prostaglandin synthesis should reveal and predict a person's benefits vs. toxicity resulting from the NSAID treatment.Entities:
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Year: 2006 PMID： 17234129
Source DB: PubMed Journal: Discov Med ISSN： 1539-6509 Impact factor: 2.970