Literature DB >> 17234123

Defeating drug resistance in cancer.

Michael M Gottesman1, Joseph Ludwig, Di Xia, Gergely Szakács.   

Abstract

Multiple resistance to cytotoxic cancer drugs dramatically reduces the effectiveness of these drugs on many occasions. ABC (ATP-binding cassette) transporters pump out cytotoxic cancer drugs from cells, preventing them from reaching therapeutic levels. However, co-administration ABC transporter inhibitors with cytotoxic cancer drugs did not effectively improve the treatment outcome. The mechanisms and remedies are discussed.

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Year:  2006        PMID： 17234123

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  23 in total

1.  Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.

Authors:  Albert A De Vera; Pranav Gupta; Zining Lei; Dan Liao; Silpa Narayanan; Qiuxu Teng; Sandra E Reznik; Zhe-Sheng Chen
Journal:  Cancer Lett       Date:  2018-11-01       Impact factor: 8.679

2.  Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.

Authors:  Yun-Kai Zhang; Yi-Jun Wang; Zi-Ning Lei; Guan-Nan Zhang; Xiao-Yu Zhang; De-Shen Wang; Sweilem B Al-Rihani; Suneet Shukla; Suresh V Ambudkar; Amal Kaddoumi; Zhi Shi; Zhe-Sheng Chen
Journal:  Cancer Lett       Date:  2018-10-28       Impact factor: 8.679

Review 3.  The challenge of drug resistance in cancer treatment: a current overview.

Authors:  Michail Nikolaou; Athanasia Pavlopoulou; Alexandros G Georgakilas; Efthymios Kyrodimos
Journal:  Clin Exp Metastasis       Date:  2018-05-24       Impact factor: 5.150

Review 4.  Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets.

Authors:  Armelle T Mbaveng; Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2017-06-02       Impact factor: 5.810

5.  Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein.

Authors:  Lothar Esser; Suneet Shukla; Fei Zhou; Suresh V Ambudkar; Di Xia
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2016-07-27       Impact factor: 1.056

Review 6.  ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target.

Authors:  Warren Davis; Kenneth D Tew
Journal:  Biochem Pharmacol       Date:  2017-12-06       Impact factor: 5.858

7.  Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL.

Authors:  Paloma S Souza; James P Madigan; Jean-Pierre Gillet; Khyati Kapoor; Suresh V Ambudkar; Raquel C Maia; Michael M Gottesman; King Leung Fung
Journal:  Exp Cell Res       Date:  2015-06-19       Impact factor: 3.905

Review 8.  ABC transporters, drug resistance, and cancer stem cells.

Authors:  Michael Dean
Journal:  J Mammary Gland Biol Neoplasia       Date:  2009-02-18       Impact factor: 2.673

Review 9.  Application of Computational Biology and Artificial Intelligence Technologies in Cancer Precision Drug Discovery.

Authors:  Nagasundaram Nagarajan; Edward K Y Yapp; Nguyen Quoc Khanh Le; Balu Kamaraj; Abeer Mohammed Al-Subaie; Hui-Yuan Yeh
Journal:  Biomed Res Int       Date:  2019-11-11       Impact factor: 3.411

10.  Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment.

Authors:  Gopalakrishnan Aridoss; Bo Zhou; David L Hermanson; Nicholas P Bleeker; Chengguo Xing
Journal:  J Med Chem       Date:  2012-05-23       Impact factor: 7.446
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