AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFalpha and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFalpha levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFalpha levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFalpha were significantly lower than in patients with tuberculous ascites.
AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFalpha and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFalpha levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascitesleptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFalpha levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFalpha were significantly lower than in patients with tuberculous ascites.
Authors: R Testa; R Franceschini; E Giannini; A Cataldi; F Botta; A Fasoli; P Tenerelli; E Rolandi; T Barreca Journal: J Hepatol Date: 2000-07 Impact factor: 25.083
Authors: K Demir; A Okten; S Kaymakoglu; D Dincer; F Besisik; U Cevikbas; S Ozdil; G Bostas; Z Mungan; Y Cakaloglu Journal: Eur J Gastroenterol Hepatol Date: 2001-05 Impact factor: 2.566
Authors: Reinout van Crevel; Elvina Karyadi; Mihai G Netea; Hans Verhoef; Ronald H H Nelwan; Clive E West; Jos W M van der Meer Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958
Authors: T Piche; F Vandenbos; A Abakar-Mahamat; G Vanbiervliet; E M Barjoan; G Calle; J Giudicelli; B Ferrua; C Laffont; S Benzaken; A Tran Journal: J Viral Hepat Date: 2004-01 Impact factor: 3.728
Authors: M Föcker; N Timmesfeld; S Scherag; K Bühren; M Langkamp; A Dempfle; E M Sheridan; M de Zwaan; C Fleischhaker; W Herzog; K Egberts; S Zipfel; B Herpertz-Dahlmann; J Hebebrand Journal: J Neural Transm (Vienna) Date: 2011-01-22 Impact factor: 3.575