| Literature DB >> 17230458 |
Laurie J Ozelius1, Tatiana Foroud, Susanne May, Geetha Senthil, Paola Sandroni, Phillip A Low, Stephen Reich, Amy Colcher, Matthew B Stern, William G Ondo, Joseph Jankovic, Neng Huang, Caroline M Tanner, Peter Novak, Sid Gilman, Frederick J Marshall, G Frederick Wooten, Thomas C Chelimsky, Clifford W Shults.
Abstract
Multiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in approximately 1% of sporadic cases of Parkinsonism. In a well-characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA. (c) 2006 Movement Disorder Society.Entities:
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Year: 2007 PMID： 17230458 DOI： 10.1002/mds.21343
Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338