Literature DB >> 17229700

Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates.

Gabriele Neumann1, Thomas W Geisbert, Hideki Ebihara, Joan B Geisbert, Kathleen M Daddario-DiCaprio, Heinz Feldmann, Yoshihiro Kawaoka.   

Abstract

Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable differences in disease progression, hematology, serum biochemistry, virus titers, or lethality in nonhuman primates infected with an Ebola virus lacking the furin recognition sequence compared to those infected with wild-type virus. We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17229700      PMCID： PMC1866002          DOI： 10.1128/JVI.02486-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

1.  Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity.

Authors:  V E Volchkov; V A Volchkova; E Muhlberger; L V Kolesnikova; M Weik; O Dolnik; H D Klenk
Journal:  Science       Date:  2001-02-01       Impact factor: 47.728

Review 2.  Understanding influenza virus pathogenicity.

Authors:  W Garten; H D Klenk
Journal:  Trends Microbiol       Date:  1999-03       Impact factor: 17.079

3.  Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture.

Authors:  Gabriele Neumann; Heinz Feldmann; Shinji Watanabe; Igor Lukashevich; Yoshihiro Kawaoka
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

4.  Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein.

Authors:  Kathryn Schornberg; Shutoku Matsuyama; Kirsten Kabsch; Sue Delos; Amy Bouton; Judith White
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

5.  Endoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function.

Authors:  R J Wool-Lewis; P Bates
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

6.  Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies.

Authors:  H Ito; S Watanabe; A Takada; Y Kawaoka
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

7.  Processing of the Ebola virus glycoprotein by the proprotein convertase furin.

Authors:  V E Volchkov; H Feldmann; V A Volchkova; H D Klenk
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

8.  Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.

Authors:  Thomas W Geisbert; Howard A Young; Peter B Jahrling; Kelly J Davis; Tom Larsen; Elliott Kagan; Lisa E Hensley
Journal:  Am J Pathol       Date:  2003-12       Impact factor: 4.307

9.  Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.

Authors:  Thomas W Geisbert; Lisa E Hensley; Tom Larsen; Howard A Young; Douglas S Reed; Joan B Geisbert; Dana P Scott; Elliott Kagan; Peter B Jahrling; Kelly J Davis
Journal:  Am J Pathol       Date:  2003-12       Impact factor: 4.307

10.  Biochemical analysis of the secreted and virion glycoproteins of Ebola virus.

Authors:  A Sanchez; Z Y Yang; L Xu; G J Nabel; T Crews; C J Peters
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103
View more
  29 in total

Review 1.  Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme.

Authors:  Judith M White; Sue E Delos; Matthew Brecher; Kathryn Schornberg
Journal:  Crit Rev Biochem Mol Biol       Date:  2008 May-Jun       Impact factor: 8.250

2.  A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry.

Authors:  Anthony C Wong; Rohini G Sandesara; Nirupama Mulherkar; Sean P Whelan; Kartik Chandran
Journal:  J Virol       Date:  2010-01       Impact factor: 5.103

Review 3.  Filovirus entry into cells - new insights.

Authors:  Emily Happy Miller; Kartik Chandran
Journal:  Curr Opin Virol       Date:  2012-03-23       Impact factor: 7.090

4.  Characterization of the receptor-binding domain of Ebola glycoprotein in viral entry.

Authors:  Jizhen Wang; Balaji Manicassamy; Michael Caffrey; Lijun Rong
Journal:  Virol Sin       Date:  2011-06-12       Impact factor: 4.327

Review 5.  Filovirus entry.

Authors:  Graham Simmons
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622

Review 6.  Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever viruses.

Authors:  Thomas Hoenen; Allison Groseth; Fabian de Kok-Mercado; Jens H Kuhn; Victoria Wahl-Jensen
Journal:  Antiviral Res       Date:  2011-06-14       Impact factor: 5.970

7.  Ebolavirus glycoprotein structure and mechanism of entry.

Authors:  Jeffrey E Lee; Erica Ollmann Saphire
Journal:  Future Virol       Date:  2009       Impact factor: 1.831

8.  Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity.

Authors:  Eric Bergeron; Martin J Vincent; Stuart T Nichol
Journal:  J Virol       Date:  2007-09-26       Impact factor: 5.103

9.  Novel mutations in Marburg virus glycoprotein associated with viral evasion from antibody mediated immune pressure.

Authors:  Masahiro Kajihara; Eri Nakayama; Andrea Marzi; Manabu Igarashi; Heinz Feldmann; Ayato Takada
Journal:  J Gen Virol       Date:  2013-01-03       Impact factor: 3.891

10.  A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species- and cell-type-specific manner.

Authors:  Osvaldo Martinez; Esther Ndungo; Lee Tantral; Emily Happy Miller; Lawrence W Leung; Kartik Chandran; Christopher F Basler
Journal:  J Virol       Date:  2013-01-09       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.