| Literature DB >> 17229493 |
C T Bauch1, Arni S R Srinivasa Rao, B Z Pham, M Krahn, V Gilca, B Duval, M H Chen, A C Tricco.
Abstract
Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52, 36, 31%) and mortality attributable to HAV by 56% (respectively 45, 26, 25%), relative to continued targeted vaccination, over 80 years.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17229493 DOI： 10.1016/j.vaccine.2006.11.020
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641