Literature DB >> 17229476

Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.

Joshua D Dowell1, Shih-Chong Tsai, Dora C Dias-Santagata, Hidehiro Nakajima, Zhuo Wang, Wuqiang Zhu, Loren J Field.   

Abstract

p193/CUL7 is an E3 ubiquitin ligase initially identified as an SV40 Large T Antigen binding protein. Expression of a dominant interfering variant of mouse p193/CUL7 (designated 1152stop) conferred resistance to MG132- and etoposide-induced apoptosis in U2OS cells. Immune precipitation/Western analyses revealed that endogenous p193/CUL7 formed a complex with Parc (a recently identified parkin-like ubiquitin ligase) and p53. Apoptosis resistance did not result from 1152stop-mediated disruption of the endogenous p193/CUL7 binding partners. Moreover, 1152stop molecule did not directly bind to endogenous p193/CUL7, Parc or p53. These data suggested a role for p193/CUL7 in the regulation of apoptosis independently of p53 and Parc activity.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17229476      PMCID： PMC1876763          DOI： 10.1016/j.bbamcr.2006.11.020

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  36 in total

Review 1.  Deadly encounter: ubiquitin meets apoptosis.

Authors:  Veronika Jesenberger; Stefan Jentsch
Journal:  Nat Rev Mol Cell Biol       Date:  2002-02       Impact factor: 94.444

2.  Coexpression of mutant p53 and p193 renders embryonic stem cell-derived cardiomyocytes responsive to the growth-promoting activities of adenoviral E1A.

Authors:  K B Pasumarthi; S C Tsai; L J Field
Journal:  Circ Res       Date:  2001-05-25       Impact factor: 17.367

3.  CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.

Authors:  Dora C Dias; Georgia Dolios; Rong Wang; Zhen-Qiang Pan
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-12       Impact factor: 11.205

4.  Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.

Authors:  H C Ardley; N G Tan; S A Rose; A F Markham; P A Robinson
Journal:  J Biol Chem       Date:  2001-03-13       Impact factor: 5.157

5.  The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.

Authors:  Paola Zacchi; Monica Gostissa; Takafumi Uchida; Clio Salvagno; Fabio Avolio; Stefano Volinia; Ze'ev Ronai; Giovanni Blandino; Claudio Schneider; Giannino Del Sal
Journal:  Nature       Date:  2002-10-02       Impact factor: 49.962

6.  Parc: a cytoplasmic anchor for p53.

Authors:  Anatoly Y Nikolaev; Muyang Li; Norbert Puskas; Jun Qin; Wei Gu
Journal:  Cell       Date:  2003-01-10       Impact factor: 41.582

7.  Inducible p27(Kip1) expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors.

Authors:  H C A Drexler; S Pebler
Journal:  Cell Death Differ       Date:  2003-03       Impact factor: 15.828

8.  p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.

Authors:  Andreas Villunger; Ewa M Michalak; Leigh Coultas; Franziska Müllauer; Gunther Böck; Michael J Ausserlechner; Jerry M Adams; Andreas Strasser
Journal:  Science       Date:  2003-09-18       Impact factor: 47.728

9.  G2 arrest in response to topoisomerase II inhibitors: the role of p53.

Authors:  Brad Clifford; Milos Beljin; George R Stark; William R Taylor
Journal:  Cancer Res       Date:  2003-07-15       Impact factor: 12.701

10.  Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.

Authors:  Takehiro Arai; Jocelyn S Kasper; Jeffrey R Skaar; Syed Hamid Ali; Chiaki Takahashi; James A DeCaprio
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-06       Impact factor: 11.205
View more
  6 in total

1.  Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.

Authors:  Thomas Fleischer; Arnoldo Frigessi; Kevin C Johnson; Hege Edvardsen; Nizar Touleimat; Jovana Klajic; Margit Lh Riis; Vilde D Haakensen; Fredrik Wärnberg; Bjørn Naume; Aslaug Helland; Anne-Lise Børresen-Dale; Jörg Tost; Brock C Christensen; Vessela N Kristensen
Journal:  Genome Biol       Date:  2014-08-22       Impact factor: 13.583

2.  Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

Authors:  Pu Wang; Feng Yan; Zhijun Li; Yanbao Yu; Scott E Parnell; Yue Xiong
Journal:  J Clin Invest       Date:  2019-07-25       Impact factor: 14.808

3.  FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest.

Authors:  Hsiang Wen; Namhun Kim; Ernesto J Fuentes; Adam Mallinger; Pedro Gonzalez-Alegre; Kevin A Glenn
Journal:  Cell Cycle       Date:  2010-11-15       Impact factor: 4.534

4.  Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells.

Authors:  Xiaorong Zhao; Ramiro J Madden-Fuentes; Becky X Lou; James M Pipas; Jeannine Gerhardt; Christopher J Rigell; Ellen Fanning
Journal:  J Virol       Date:  2008-03-19       Impact factor: 5.103

5.  The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.

Authors:  Xinsong Xu; Antonio Sarikas; Dora C Dias-Santagata; Georgia Dolios; Pascal J Lafontant; Shih-Chong Tsai; Wuqiang Zhu; Hidehiro Nakajima; Hisako O Nakajima; Loren J Field; Rong Wang; Zhen-Qiang Pan
Journal:  Mol Cell       Date:  2008-05-23       Impact factor: 17.970

Review 6.  The cullin7 E3 ubiquitin ligase: a novel player in growth control.

Authors:  Antonio Sarikas; Xinsong Xu; Loren J Field; Zhen-Qiang Pan
Journal:  Cell Cycle       Date:  2008-10-04       Impact factor: 4.534
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.