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Literature DB >> 17228858

Advances in development of dopaminergic aporphinoids.

Ao Zhang¹, Yi Zhang, Alan R Branfman, Ross J Baldessarini, John L Neumeyer.

Abstract

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Year: 2007 PMID： 17228858 DOI： 10.1021/jm060959i

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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24 in total

1. Exploring structure-selectivity relationships of biogenic amine GPCR antagonists using similarity searching and dynamic compound mapping.

Authors: Ingo Vogt; Hany E A Ahmed; Jens Auer; Jürgen Bajorath
Journal: Mol Divers Date: 2008-03-04 Impact factor: 2.943

2. Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C.

Authors: Shashikanth Ponnala; Nirav Kapadia; Hernán A Navarro; Wayne W Harding
Journal: Chem Biol Drug Des Date: 2014-06-03 Impact factor: 2.817

3. Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells.

Authors: Dorival Mendes Rodrigues-Junior; Nicolie Melanie de Almeida Pontes; Gabriela Estrela de Albuquerque; Viviane Carlin; Givago Prado Perecim; Cristiano Raminelli; André Luiz Vettore
Journal: Invest New Drugs Date: 2019-05-17 Impact factor: 3.850

Advances in development of dopaminergic aporphinoids.

1. Exploring structure-selectivity relationships of biogenic amine GPCR antagonists using similarity searching and dynamic compound mapping.

2. Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C.

3. Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells.

4. Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study.

5. Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.

6. Identification of C10 nitrogen-containing aporphines with dopamine D₁ versus D₅ receptor selectivity.

7. Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine.

8. Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities.

9. Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors

10. C4 phenyl aporphines with selective h5-HT(2B) receptor affinity.