Literature DB >> 17227227

Nuclear factor-kappa B: a transcription factor for all seasons.

Bharat B Aggarwal.   

Abstract

NF-kappaB, first discovered in 1986 in the nucleus of B cells as an immunoglobulin-kappa light chain enhancer, is today known as a transcription factor that is ubiquitously present in all cell types (not just B cells). It is conserved from drosophila to man, resides in the cytoplasm (not nucleus) in the resting state and binds to the promoter of > 400 different genes (not just immunoglobulin). Both NF-kappaB and TNF are essential components of the immune system, with their critical physiological role being in the immune defense.

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Year:  2007        PMID： 17227227     DOI： 10.1517/14728222.11.2.109

Source DB:  PubMed          Journal:  Expert Opin Ther Targets        ISSN： 1472-8222            Impact factor:   6.902


  5 in total

1.  A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Authors:  Kuzhuvelil B Harikumar; Ajaikumar B Kunnumakkara; Nobuo Ochi; Zhimin Tong; Amit Deorukhkar; Bokyung Sung; Lloyd Kelland; Stephen Jamieson; Rachel Sutherland; Tony Raynham; Mark Charles; Azadeh Bagherzadeh; Azadeh Bagherazadeh; Caroline Foxton; Alexandra Boakes; Muddasar Farooq; Dipen Maru; Parmeswaran Diagaradjane; Yoichi Matsuo; James Sinnett-Smith; Juri Gelovani; Sunil Krishnan; Bharat B Aggarwal; Enrique Rozengurt; Christopher R Ireson; Sushovan Guha
Journal:  Mol Cancer Ther       Date:  2010-05-04       Impact factor: 6.261

2.  Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition.

Authors:  Wayne S Orr; Jason W Denbo; Karim R Saab; Adrianne L Myers; Catherine Y Ng; Junfang Zhou; Christopher L Morton; Lawrence M Pfeffer; Andrew M Davidoff
Journal:  Surgery       Date:  2012-01-28       Impact factor: 3.982

3.  Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.

Authors:  Yuli Xie; ShiXian Deng; Craig J Thomas; Yidong Liu; Ya-Qin Zhang; Alison Rinderspacher; Wenwei Huang; Gangli Gong; Michael Wyler; Efithia Cayanis; Nathalie Aulner; Udo Többen; Caty Chung; Sergey Pampou; Noel Southall; Dusica Vidović; Stephan Schürer; Lars Branden; R Eric Davis; Louis M Staudt; James Inglese; Christopher P Austin; Donald W Landry; Deborah H Smith; Douglas S Auld
Journal:  Bioorg Med Chem Lett       Date:  2007-10-30       Impact factor: 2.823

4.  Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer.

Authors:  Fanny Comblain; Christelle Sanchez; Isabelle Lesponne; Marc Balligand; Samuel Serisier; Yves Henrotin
Journal:  PLoS One       Date:  2015-03-23       Impact factor: 3.240

Review 5.  Oxidative stress in female cancers.

Authors:  Gloria M Calaf; Ulises Urzua; Lara Termini; Francisco Aguayo
Journal:  Oncotarget       Date:  2018-05-04
  5 in total

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