Literature DB >> 17226944

Metal-based turn-on fluorescent probes for sensing nitric oxide.

Mi Hee Lim1, Stephen J Lippard.   

Abstract

Nitric oxide, a reactive free radical, regulates a variety of biological processes. The absence of tools to detect NO directly, rapidly, specifically, and selectively motivated us to synthesize metal-based fluorescent probes to visualize the presence of NO. We prepared and investigated Co(II), Fe(II), Ru(II), Rh(II), and Cu(II) complexes as turn-on fluorescent NO sensors. Our exploration has provided insight into how the interaction of transition-metal centers with nitric oxide can be utilized for NO sensing.

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Year:  2007        PMID: 17226944     DOI: 10.1021/ar950149t

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN: 0001-4842            Impact factor:   22.384


  30 in total

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