Literature DB >> 1722474

cDNA encoding murine FK506-binding protein (FKBP): nucleotide and deduced amino acid sequence.

P A Nelson1, J A Lippke, M A Murcko, S L Rosborough, D A Peattie.   

Abstract

A FKBP cDNA encoding murine FK506 binding protein (FKBP) has been cloned, and its complete nucleotide sequence has been determined. The open reading frame within the 1556-bp cDNA segment encodes an 108 amino acid (aa) protein that differs from the human FKBP by three aa and from the bovine FKBP by five aa. Molecular modeling of the protein places the aa substitutions at positions not directly involved in drug binding or interaction with the potential drug target protein, calcineurin A.

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Year:  1991        PMID： 1722474     DOI： 10.1016/0378-1119(91)90617-k

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  5 in total

1.  Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region.

Authors:  R Banholzer; A P Nair; H H Hirsch; X F Ming; C Moroni
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

2.  Rapamycin inhibits vascular smooth muscle cell migration.

Authors:  M Poon; S O Marx; R Gallo; J J Badimon; M B Taubman; A R Marks
Journal:  J Clin Invest       Date:  1996-11-15       Impact factor: 14.808

3.  Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation.

Authors:  W C Yeh; T K Li; B E Bierer; S L McKnight
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

4.  Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

Authors:  D A Peattie; M W Harding; M A Fleming; M T DeCenzo; J A Lippke; D J Livingston; M Benasutti
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

5.  Synthesis in Escherichia coli of two smaller enzymically active analogues of Coxiella burnetii macrophage infectivity potentiator (CbMip) protein utilizing a single open reading frame from the cbmip gene.

Authors:  Y Y Mo; J Seshu; D Wang; L P Mallavia
Journal:  Biochem J       Date:  1998-10-01       Impact factor: 3.857
  5 in total

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