Literature DB >> 17224652

Conflicting roles for p63 in skin development and carcinogenesis.

Maranke I Koster1, Daisy Dai, Dennis R Roop.   

Abstract

Epidermal morphogenesis is a complex process that culminates in the formation of a barrier that protects the organism from environmental substances and dehydration. p63, a transcription factor, is essential for normal epidermal morphogenesis as demonstrated by the failure of mice lacking p63 expression to develop an epidermis. However, since two independently generated p63(-/-) mouse models displayed different phenotypes, the role of p63 in epidermal morphogenesis has remained controversial. Furthermore, the tumor susceptibility phenotypes of both p63(-/-) mouse models were strikingly different. In this review, we discuss these conflicting findings and provide evidence for various roles of p63 in the epidermis under normal and pathological conditions.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17224652     DOI： 10.4161/cc.6.3.3792

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  20 in total

1.  p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells.

Authors:  Andrei N Mardaryev; Michal R Gdula; Joanne L Yarker; Vladimir U Emelianov; Vladimir N Emelianov; Krzysztof Poterlowicz; Andrey A Sharov; Tatyana Y Sharova; Julie A Scarpa; Boris Joffe; Irina Solovei; Pierre Chambon; Vladimir A Botchkarev; Michael Y Fessing
Journal:  Development       Date:  2014-01       Impact factor: 6.868

2.  Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer.

Authors:  B A Patrick; X Gong; A K Jaiswal
Journal:  Oncogene       Date:  2010-11-01       Impact factor: 9.867

3.  beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus.

Authors:  J-W Jeong; H S Lee; H L Franco; R R Broaddus; M M Taketo; S Y Tsai; J P Lydon; F J DeMayo
Journal:  Oncogene       Date:  2008-09-22       Impact factor: 9.867

4.  Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.

Authors:  Curtis R Pickering; Jiexin Zhang; Suk Young Yoo; Linnea Bengtsson; Shhyam Moorthy; David M Neskey; Mei Zhao; Marcus V Ortega Alves; Kyle Chang; Jennifer Drummond; Elsa Cortez; Tong-Xin Xie; Di Zhang; Woonbok Chung; Jean-Pierre J Issa; Patrick A Zweidler-McKay; Xifeng Wu; Adel K El-Naggar; John N Weinstein; Jing Wang; Donna M Muzny; Richard A Gibbs; David A Wheeler; Jeffrey N Myers; Mitchell J Frederick
Journal:  Cancer Discov       Date:  2013-04-25       Impact factor: 39.397

5.  Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences.

Authors:  Weiguo Feng; Sonia M Leach; Hannah Tipney; Tzulip Phang; Mark Geraci; Richard A Spritz; Lawrence E Hunter; Trevor Williams
Journal:  PLoS One       Date:  2009-12-16       Impact factor: 3.240

6.  NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.

Authors:  Kristina Heyne; Vivienne Willnecker; Julia Schneider; Marcel Conrad; Nina Raulf; Roland Schüle; Klaus Roemer
Journal:  Nucleic Acids Res       Date:  2010-01-31       Impact factor: 16.971

7.  Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.

Authors:  Briana Lee; Alvaro Villarreal-Ponce; Magid Fallahi; Jeremy Ovadia; Peng Sun; Qian-Chun Yu; Seiji Ito; Satrajit Sinha; Qing Nie; Xing Dai
Journal:  Dev Cell       Date:  2014-04-14       Impact factor: 12.270

8.  Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.

Authors:  Jun Shen; Roberto J Barrios; Anil K Jaiswal
Journal:  Cancer Res       Date:  2010-01-26       Impact factor: 12.701

9.  ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis.

Authors:  R Shalom-Feuerstein; A M Lena; H Zhou; S De La Forest Divonne; H Van Bokhoven; E Candi; G Melino; D Aberdam
Journal:  Cell Death Differ       Date:  2010-12-03       Impact factor: 15.828

10.  ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells.

Authors:  Corrie L Gallant-Behm; Joaquín M Espinosa
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.