OBJECTIVE: To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle. METHODS: Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator (2.5 GHz, 150 W) for 20 min. At 1 day after the MHT, a muscle sample was taken from the heated leg. A control sample was taken from the unheated leg on another day of the MHT. For both legs, HSP90, HSP72 and HSP27 levels were compared. RESULTS: The HSP90, HSP72 and HSP27 levels in heated legs were significantly higher than those in control legs (p<0.05). CONCLUSIONS: Application of MHT can increase the levels of several HSPs in human skeletal muscle.
OBJECTIVE: To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle. METHODS: Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator (2.5 GHz, 150 W) for 20 min. At 1 day after the MHT, a muscle sample was taken from the heated leg. A control sample was taken from the unheated leg on another day of the MHT. For both legs, HSP90, HSP72 and HSP27 levels were compared. RESULTS: The HSP90, HSP72 and HSP27 levels in heated legs were significantly higher than those in control legs (p<0.05). CONCLUSIONS: Application of MHT can increase the levels of several HSPs in human skeletal muscle.
Authors: James P Morton; Don P M MacLaren; Nigel T Cable; Thomas Bongers; Richard D Griffiths; Iain T Campbell; Louise Evans; Anna Kayani; Anne McArdle; Barry Drust Journal: J Appl Physiol (1985) Date: 2006-03-24
Authors: Chad Touchberry; Tung Le; Scott Richmond; Mike Prewitt; David Beck; David Carr; Phil Vardiman; Philip Gallagher Journal: Eur J Appl Physiol Date: 2007-10-18 Impact factor: 3.078