Literature DB >> 1722422

Regulatory volume decrease in small intestinal crypts is inhibited by K+ and Cl- channel blockers.

J A O'Brien1, R J Walters, F V Sepúlveda.   

Abstract

Total crypt volume has been estimated by analysis of photographic images of intact viable crypts isolated from guinea-pig small intestine. Exposing these crypts to a hypotonic medium, led to transient swelling followed by regulatory volume decrease (RVD) in 12-20 min. RVD was blocked by inhibitors of K+ and Cl- conductance, suggesting that it occurs by activation of K+ and Cl- permeability pathways and loss of these ions.

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Year:  1991        PMID： 1722422     DOI： 10.1016/0005-2736(91)90093-n

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Volume regulation following hypotonic shock in isolated crypts of mouse distal colon.

Authors:  O Mignen; C Le Gall; B J Harvey; S Thomas
Journal:  J Physiol       Date:  1999-03-01       Impact factor: 5.182

2.  Regulatory volume increase after hypertonicity- or vasoactive-intestinal-peptide-induced cell-volume decrease in small-intestinal crypts is dependent on Na(+)-K(+)-2Cl- cotransport.

Authors:  J A O'Brien; R J Walters; M A Valverde; F V Sepúlveda
Journal:  Pflugers Arch       Date:  1993-04       Impact factor: 3.657

3.  Activation of basolateral Cl- channels in the rat colonic epithelium during regulatory volume decrease.

Authors:  M Diener; M Nobles; W Rummel
Journal:  Pflugers Arch       Date:  1992-09       Impact factor: 3.657

4.  Membrane conductance and cell volume changes evoked by vasoactive intestinal polypeptide and carbachol in small intestinal crypts.

Authors:  R J Walters; J A O'Brien; M A Valverde; F V Sepúlveda
Journal:  Pflugers Arch       Date:  1992-09       Impact factor: 3.657

5.  Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca(2+)-mediated secretagogue-induced volume decrease in small-intestinal crypts.

Authors:  M A Valverde; J A O'Brien; F V Sepúlveda; R Ratcliff; M J Evans; W H Colledge
Journal:  Pflugers Arch       Date:  1993-12       Impact factor: 3.657

6.  Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.

Authors:  M A Valverde; J A O'Brien; F V Sepúlveda; R A Ratcliff; M J Evans; W H Colledge
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-26       Impact factor: 11.205

7.  The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

Authors:  A E Trezise; P R Romano; D R Gill; S C Hyde; F V Sepúlveda; M Buchwald; C F Higgins
Journal:  EMBO J       Date:  1992-12       Impact factor: 11.598

8.  Voltage- and time-dependent K+ channel currents in the basolateral membrane of villus enterocytes isolated from guinea pig small intestine.

Authors:  H Tatsuta; S Ueda; S Morishima; Y Okada
Journal:  J Gen Physiol       Date:  1994-03       Impact factor: 4.086
  8 in total

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