Literature DB >> 17224211

Protection against heartwater by DNA immunisation with four Ehrlichia ruminantium open reading frames.

A Pretorius1, N E Collins, H C Steyn, F van Strijp, M van Kleef, B A Allsopp.   

Abstract

We have reported previously that a recombinant DNA vaccine consisting of four Ehrlichia ruminantium (Welgevonden) open reading frames (ORFs) known as the 1H12 cocktail provided protection against a virulent E. ruminantium (Welgevonden) needle challenge in sheep. In this study, we have investigated the vaccine effectiveness of two other cocktails of E. ruminantium (Welgevonden) ORFs, as well as single ORFs from the 1H12 cocktail, to protect sheep against a virulent needle challenge with the homologous strain. Each individual 1H12 ORF provided protection, but all the animals vaccinated with the other cocktails succumbed to the challenge.

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Year:  2006        PMID： 17224211     DOI： 10.1016/j.vaccine.2006.11.061

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  4 in total

Review 1.  Progress and obstacles in vaccine development for the ehrlichioses.

Authors:  Jere W McBride; David H Walker
Journal:  Expert Rev Vaccines       Date:  2010-09       Impact factor: 5.217

2.  Proteomic profiling of the outer membrane fraction of the obligate intracellular bacterial pathogen Ehrlichia ruminantium.

Authors:  Amal Moumène; Isabel Marcelino; Miguel Ventosa; Olivier Gros; Thierry Lefrançois; Nathalie Vachiéry; Damien F Meyer; Ana V Coelho
Journal:  PLoS One       Date:  2015-02-24       Impact factor: 3.240

3.  A glycosylated recombinant subunit candidate vaccine consisting of Ehrlichia ruminantium major antigenic protein1 induces specific humoral and Th1 type cell responses in sheep.

Authors:  Bonto Faburay; Jodi McGill; Frans Jongejan
Journal:  PLoS One       Date:  2017-09-28       Impact factor: 3.240

4.  Cellular immune responses induced <i>in vitro</i> by <i>Ehrlichia ruminantium</i> secreted proteins and identification of vaccine candidate peptides.

Authors:  Nontobeko Thema; Alri Pretorius; Selaelo I Tshilwane; Junita Liebenberg; Helena Steyn; Mirinda Van Kleef
Journal:  Onderstepoort J Vet Res       Date:  2016-08-30       Impact factor: 1.792
  4 in total

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