| Literature DB >> 17223910 |
B Eggleston1, M Patience, S Edwards, T Adamkiewicz, G R Buchanan, S C Davies, R Dickerhoff, S Donfield, S A Feig, R H Giller, A Haight, J Horan, L L Hsu, N Kamani, P Lane, J E Levine, D Margolis, T B Moore, K Ohene-Frempong, R Redding-Lallinger, I A G Roberts, Z R Rogers, J E Sanders, J P Scott, B Sleight, A A Thompson, K M Sullivan, M C Walters.
Abstract
Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.Entities:
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Year: 2007 PMID： 17223910 DOI： 10.1111/j.1365-2141.2006.06486.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998