Literature DB >> 17222947

Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease.

Tiina M Kauppinen1.   

Abstract

Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the interest toward PARP-1 as a therapeutic target has peaked. This review introduces mechanism of PARP-1 activation, the role of PARP-1 in cell physiology and pathology, and discusses the potential of PARP-1 inhibition as a therapy in acute and chronic CNS diseases.

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Year:  2007        PMID： 17222947     DOI： 10.1016/j.neuint.2006.11.010

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  13 in total

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Review 2.  Natural inhibitors of poly(ADP-ribose) polymerase-1.

Authors:  Marek Banasik; Todd Stedeford; Robert P Strosznajder
Journal:  Mol Neurobiol       Date:  2012-04-04       Impact factor: 5.590

3.  Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kappaB-dependent signaling.

Authors:  Paola Castri; Yang-Ja Lee; Todd Ponzio; Dragan Maric; Maria Spatz; Joliet Bembry; John Hallenbeck
Journal:  Biochim Biophys Acta       Date:  2014-03

4.  Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons.

Authors:  Maja Jazvinšćak Jembrek; Lidija Vuković; Jasmina Puhović; Julija Erhardt; Nada Oršolić
Journal:  J Mol Neurosci       Date:  2012-03-14       Impact factor: 3.444

Review 5.  The importance of NAD in multiple sclerosis.

Authors:  W Todd Penberthy; Ikuo Tsunoda
Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

6.  PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.

Authors:  Vimal Selvaraj; Mangala M Soundarapandian; Olga Chechneva; Ambrose J Williams; Maxim K Sidorov; Athena M Soulika; David E Pleasure; Wenbin Deng
Journal:  J Biol Chem       Date:  2009-07-23       Impact factor: 5.157

7.  Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.

Authors:  K Nho; J J Corneveaux; S Kim; H Lin; S L Risacher; L Shen; S Swaminathan; V K Ramanan; Y Liu; T Foroud; M H Inlow; A L Siniard; R A Reiman; P S Aisen; R C Petersen; R C Green; C R Jack; M W Weiner; C T Baldwin; K Lunetta; L A Farrer; S J Furney; S Lovestone; A Simmons; P Mecocci; B Vellas; M Tsolaki; I Kloszewska; H Soininen; B C McDonald; M R Farlow; B Ghetti; M J Huentelman; A J Saykin
Journal:  Mol Psychiatry       Date:  2013-04-23       Impact factor: 15.992

Review 8.  Drug targets for traumatic brain injury from poly(ADP-ribose)polymerase pathway modulation.

Authors:  Valerie C Besson
Journal:  Br J Pharmacol       Date:  2009-04-09       Impact factor: 8.739

9.  Ethanol-mediated DNA damage and PARP-1 apoptotic responses in cultured fetal cortical neurons.

Authors:  Priscilla P Cherian; Steven Schenker; George I Henderson
Journal:  Alcohol Clin Exp Res       Date:  2008-08-20       Impact factor: 3.455

10.  Nicotinic acid-mediated activation of both membrane and nuclear receptors towards therapeutic glucocorticoid mimetics for treating multiple sclerosis.

Authors:  W Todd Penberthy
Journal:  PPAR Res       Date:  2009-05-17       Impact factor: 4.964
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