OBJECTIVE: To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression. METHOD: Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline. RESULTS: The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function. CONCLUSION: The BDNF val66met polymorphism may modify the association between stroke and depression.
OBJECTIVE: To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression. METHOD: Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline. RESULTS: The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function. CONCLUSION: The BDNFval66met polymorphism may modify the association between stroke and depression.
Authors: Sophiya Benjamin; Douglas R McQuoid; Guy G Potter; Martha E Payne; James R MacFall; David C Steffens; Warren D Taylor Journal: Am J Geriatr Psychiatry Date: 2010-04 Impact factor: 4.105
Authors: Aleksandra Pikula; Alexa S Beiser; Tai C Chen; Sarah R Preis; Demetrios Vorgias; Charles DeCarli; Rhoda Au; Margaret Kelly-Hayes; Carlos S Kase; Philip A Wolf; Ramachandran S Vasan; Sudha Seshadri Journal: Stroke Date: 2013-08-08 Impact factor: 7.914