BACKGROUND: Cognitive deficits of late-onset schizophrenia (LOS) patients have been reported as stable, although some prospective studies show that a sub-group develop a significant cognitive decline. Data on LOS from developing countries are scarce. OBJECTIVE: To evaluate the cognitive performance of Brazilian patients with LOS over the course of one year. METHOD: Thirteen LOS patients were evaluated at baseline and after one year with the Mini-Mental State Examination (MMSE), the CAMCOG, the Positive and Negative Symptoms Scale, the Pfeffers Activities of Daily Living (ADL), and the Neuropsychiatric Inventory (NPI). RESULTS: Cognition and activities of daily living remained stable over the course of one year [baseline MMSE= 21.31 (4.87) and CAMCOG=80.31 (16.68); end-point MMSE=20.77 (3.86) and CAMCOG=82.92 (14.42) (Z=-0.831; p=0.40); baseline ADL=4.31 (5.65); end-point ADL= 5.92 (3.86) (Z=-0.831; p=0.40)]; end-point NPI=10.54 (10.69) (Z=-0.737; p=0.46]. CONCLUSION: Like patients from developed countries, Brazilian patients with LOS do not seem to develop dementia, at least over the course of one year.
BACKGROUND:Cognitive deficits of late-onset schizophrenia (LOS) patients have been reported as stable, although some prospective studies show that a sub-group develop a significant cognitive decline. Data on LOS from developing countries are scarce. OBJECTIVE: To evaluate the cognitive performance of Brazilian patients with LOS over the course of one year. METHOD: Thirteen LOS patients were evaluated at baseline and after one year with the Mini-Mental State Examination (MMSE), the CAMCOG, the Positive and Negative Symptoms Scale, the Pfeffers Activities of Daily Living (ADL), and the Neuropsychiatric Inventory (NPI). RESULTS: Cognition and activities of daily living remained stable over the course of one year [baseline MMSE= 21.31 (4.87) and CAMCOG=80.31 (16.68); end-point MMSE=20.77 (3.86) and CAMCOG=82.92 (14.42) (Z=-0.831; p=0.40); baseline ADL=4.31 (5.65); end-point ADL= 5.92 (3.86) (Z=-0.831; p=0.40)]; end-point NPI=10.54 (10.69) (Z=-0.737; p=0.46]. CONCLUSION: Like patients from developed countries, Brazilian patients with LOS do not seem to develop dementia, at least over the course of one year.
Authors: I V Vahia; B W Palmer; C Depp; I Fellows; S Golshan; H C Kraemer; Dilip V Jeste Journal: Acta Psychiatr Scand Date: 2010-11 Impact factor: 6.392
Authors: Tarek K Rajji; Aristotle N Voineskos; Meryl A Butters; Dielle Miranda; Tamara Arenovich; Mahesh Menon; Zahinoor Ismail; Robert S Kern; Benoit H Mulsant Journal: Am J Geriatr Psychiatry Date: 2013-01-22 Impact factor: 4.105
Authors: Ruqi Tang; Hyun Ji Noh; Dongqing Wang; Snaevar Sigurdsson; Ross Swofford; Michele Perloski; Margaret Duxbury; Edward E Patterson; Julie Albright; Marta Castelhano; Adam Auton; Adam R Boyko; Guoping Feng; Kerstin Lindblad-Toh; Elinor K Karlsson Journal: Genome Biol Date: 2014-03-14 Impact factor: 13.583