Literature DB >> 17220912

JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain.

M D Tricklebank1.   

Abstract

The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe the functional role and address the therapeutic utility of this potentially highly important adrenoceptor subtype.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17220912      PMCID： PMC2189729          DOI： 10.1038/sj.bjp.0707007

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

1.  Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302.

Authors:  J Sallinen; I Höglund; M Engström; J Lehtimäki; R Virtanen; J Sirviö; S Wurster; J-M Savola; A Haapalinna
Journal:  Br J Pharmacol       Date:  2007-01-15       Impact factor: 8.739

2.  Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.

Authors:  K P Makaritsis; D E Handy; C Johns; B Kobilka; I Gavras; H Gavras
Journal:  Hypertension       Date:  1999-01       Impact factor: 10.190

3.  The alpha2C-adrenoceptor modulates GABA release in mouse striatum.

Authors:  Weilie Zhang; Gregory A Ordway
Journal:  Brain Res Mol Brain Res       Date:  2003-04-10

Review 4.  In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.

Authors:  J W Kable; L C Murrin; D B Bylund
Journal:  J Pharmacol Exp Ther       Date:  2000-04       Impact factor: 4.030

5.  Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns.

Authors:  M Björklund; J Sirviö; J Sallinen; M Scheinin; B K Kobilka; P Riekkinen
Journal:  Neuroscience       Date:  1999       Impact factor: 3.590

6.  Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice.

Authors:  M M Bücheler; K Hadamek; L Hein
Journal:  Neuroscience       Date:  2002       Impact factor: 3.590

7.  Adrenergic alpha2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice.

Authors:  J Sallinen; A Haapalinna; T Viitamaa; B K Kobilka; M Scheinin
Journal:  J Neurosci       Date:  1998-04-15       Impact factor: 6.167

8.  OPC-28326, a selective femoral vasodilator, is an alpha2C-adrenoceptor-selective antagonist.

Authors:  B Sun; S Lockyer; J Li; R Chen; M Yoshitake; J I Kambayashi
Journal:  J Pharmacol Exp Ther       Date:  2001-11       Impact factor: 4.030

9.  The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat.

Authors:  H O Kalkman; V Neumann; D Hoyer; M D Tricklebank
Journal:  Br J Pharmacol       Date:  1998-08       Impact factor: 8.739

10.  D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype.

Authors:  J Sallinen; A Haapalinna; T Viitamaa; B K Kobilka; M Scheinin
Journal:  Neuroscience       Date:  1998-10       Impact factor: 3.590
View more
  2 in total

1.  Structural determinants of the alpha2 adrenoceptor subtype selectivity.

Authors:  Liliana Ostopovici-Halip; Ramona Curpăn; Maria Mracec; Cristian G Bologa
Journal:  J Mol Graph Model       Date:  2011-05-06       Impact factor: 2.518

2.  Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors.

Authors:  Wenling Chen; Bingbing Song; Juan Carlos G Marvizón
Journal:  Neuropharmacology       Date:  2008-02-10       Impact factor: 5.250
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.