Literature DB >> 17220897

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.

Limin Wang1, Yiwei Zhao, Zhong Li, Yi Guo, Lindsay L Jones, David M Kranz, Walid Mourad, Hongmin Li.   

Abstract

'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

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Year:  2007        PMID： 17220897      PMCID： PMC3923521          DOI： 10.1038/nsmb1193

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  15 in total

1.  A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.

Authors:  M Degano; K C Garcia; V Apostolopoulos; M G Rudolph; L Teyton; I A Wilson
Journal:  Immunity       Date:  2000-03       Impact factor: 31.745

2.  Binding of Mycoplasma arthritidis-derived mitogen to human MHC class II molecules via its N terminus is modulated by invariant chain expression and its C terminus is required for T cell activation.

Authors:  M A Langlois; P Etongué-Mayer; M Ouellette; W Mourad
Journal:  Eur J Immunol       Date:  2000-06       Impact factor: 5.532

Review 3.  So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes.

Authors:  Eric J Sundberg; Yili Li; Roy A Mariuzza
Journal:  Curr Opin Immunol       Date:  2002-02       Impact factor: 7.486

4.  Staphylococcal enterotoxin H induces V alpha-specific expansion of T cells.

Authors:  Karin Petersson; Helen Pettersson; Niels Jörgen Skartved; Björn Walse; Göran Forsberg
Journal:  J Immunol       Date:  2003-04-15       Impact factor: 5.422

5.  Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex.

Authors:  Yiwei Zhao; Zhong Li; Sandra J Drozd; Yi Guo; Walid Mourad; Hongmin Li
Journal:  Structure       Date:  2004-02       Impact factor: 5.006

Review 6.  How TCRs bind MHCs, peptides, and coreceptors.

Authors:  Markus G Rudolph; Robyn L Stanfield; Ian A Wilson
Journal:  Annu Rev Immunol       Date:  2006       Impact factor: 28.527

7.  An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.

Authors:  K C Garcia; M Degano; R L Stanfield; A Brunmark; M R Jackson; P A Peterson; L Teyton; I A Wilson
Journal:  Science       Date:  1996-10-11       Impact factor: 47.728

8.  Clonal analysis of human T cell activation by the Mycoplasma arthritidis mitogen (MAS).

Authors:  M Matthes; H Schrezenmeier; J Homfeld; S Fleischer; B Malissen; H Kirchner; B Fleischer
Journal:  Eur J Immunol       Date:  1988-11       Impact factor: 5.532

Review 9.  The CD8 T cell response to staphylococcal enterotoxins.

Authors:  T Herrmann; H R MacDonald
Journal:  Semin Immunol       Date:  1993-02       Impact factor: 11.130

10.  CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response.

Authors:  Y Li; G R Sun; J R Tumang; M K Crow; S M Friedman
Journal:  J Clin Invest       Date:  1994-12       Impact factor: 14.808
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  17 in total

1.  The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.

Authors:  A K M Nur-ur Rahman; Daniel A Bonsor; Christine A Herfst; Fraser Pollard; Michael Peirce; Aaron W Wyatt; Katherine J Kasper; Joaquín Madrenas; Eric J Sundberg; John K McCormick
Journal:  J Biol Chem       Date:  2010-12-02       Impact factor: 5.157

2.  The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.

Authors:  Maria Saline; Karin E J Rödström; Gerhard Fischer; Vladislav Yu Orekhov; B Göran Karlsson; Karin Lindkvist-Petersson
Journal:  Nat Commun       Date:  2010-11-16       Impact factor: 14.919

3.  Staphylococcal superantigens cause lethal pulmonary disease in rabbits.

Authors:  Kristi L Strandberg; Jessica H Rotschafer; Sara M Vetter; Rebecca A Buonpane; David M Kranz; Patrick M Schlievert
Journal:  J Infect Dis       Date:  2010-10-27       Impact factor: 5.226

4.  A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.

Authors:  John P Cannon; Robert N Haire; Andrew T Magis; Donna D Eason; Kelley N Winfrey; Jose A Hernandez Prada; Kate M Bailey; Jean Jakoncic; Gary W Litman; David A Ostrov
Journal:  Immunity       Date:  2008-07-31       Impact factor: 31.745

Review 5.  Breaking the wall: targeting of the endothelium by pathogenic bacteria.

Authors:  Emmanuel Lemichez; Marc Lecuit; Xavier Nassif; Sandrine Bourdoulous
Journal:  Nat Rev Microbiol       Date:  2009-12-30       Impact factor: 60.633

Review 6.  TCR recognition of peptide/MHC class II complexes and superantigens.

Authors:  Eric J Sundberg; Lu Deng; Roy A Mariuzza
Journal:  Semin Immunol       Date:  2007-06-07       Impact factor: 11.130

7.  A comprehensive mathematical model for three-body binding equilibria.

Authors:  Eugene F Douglass; Chad J Miller; Gerson Sparer; Harold Shapiro; David A Spiegel
Journal:  J Am Chem Soc       Date:  2013-04-16       Impact factor: 15.419

8.  T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.

Authors:  Lei Yin; Frances Crawford; Philippa Marrack; John W Kappler; Shaodong Dai
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-22       Impact factor: 11.205

9.  Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments.

Authors:  Sarah A Richman; David H Aggen; Michelle L Dossett; David L Donermeyer; Paul M Allen; Philip D Greenberg; David M Kranz
Journal:  Mol Immunol       Date:  2008-10-29       Impact factor: 4.407

10.  Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl.

Authors:  Henry Dlaske; Hatice Karaüzüm; Elisa Monzon-Casanova; Ronald Rudolf; Lisa Starick; Ingrid Müller; Gerhild Wildner; Maria Diedrichs-Möhring; Norbert Koch; Tohru Miyoshi-Akiyama; Takehiko Uchiyama; Kurt Wonigeit; Bernhard Fleischer; Silke Overbeck; Lothar Rink; Thomas Herrmann
Journal:  Immunology       Date:  2008-12-24       Impact factor: 7.397
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