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Literature DB >> 17220399

Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters.

Saima Aslam¹, Barbara W Trautner, Venkat Ramanathan, Rabih O Darouiche.

Abstract

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

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Year: 2007 PMID： 17220399 PMCID： PMC1855497 DOI： 10.1128/AAC.00893-06

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

27 in total

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Authors: Ann-Cathrin Olofsson; Malte Hermansson; Hans Elwing
Journal: Appl Environ Microbiol Date: 2003-08 Impact factor: 4.792

29 in total

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Authors: F Bartalesi; S Veloci; F Baragli; E Mantengoli; S Guidi; A M Bartolesi; R Mannino; P Pecile; A Bartoloni
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2. Effect of different agents with potential antibiofilm activity on antimicrobial susceptibility of biofilms formed by Staphylococcus spp. isolated from implant-related infections.

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Journal: J Antibiot (Tokyo) Date: 2016-02-24 Impact factor: 2.649

3. N-acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication.

Authors: Luís Eduardo S Fontes; Ana Luiza C Martimbianco; Carolina Zanin; Rachel Riera
Journal: Cochrane Database Syst Rev Date: 2019-02-12

4. Daptomycin and tigecycline have broader effective dose ranges than vancomycin as prophylaxis against a Staphylococcus aureus surgical implant infection in mice.

Authors: Jared A Niska; Jonathan H Shahbazian; Romela Irene Ramos; Jonathan R Pribaz; Fabrizio Billi; Kevin P Francis; Lloyd S Miller
Journal: Antimicrob Agents Chemother Date: 2012-02-27 Impact factor: 5.191

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Authors: David Lebeaux; Jean-Marc Ghigo; Christophe Beloin
Journal: Microbiol Mol Biol Rev Date: 2014-09 Impact factor: 11.056