Literature DB >> 1722018

DNA methylation and cellular ageing.

J Catania1, D S Fairweather.   

Abstract

Methylated cytosine (m5C) in DNA appears to be an important modulator of the expression of some genes. There are several lines of evidence that gradual loss of m5C is relevant to in vitro cellular ageing: m5C loss occurs during cell culture; m5C loss is detectable at an early stage of culture; m5C loss appears to be related to cell division not just duration in culture; the rate of m5C loss appears to be related to in vitro lifespan of the cell strain in question; and the total loss of m5C during an in vitro lifespan is significant by comparison with induced-changes in m5C levels which effect cell growth, or cause cell-death in culture. Progressive loss of m5C in dividing cells may thus produce the multi-step cell division "clock" which underlies the Hayflick phenomenon.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1722018     DOI： 10.1016/0921-8734(91)90019-8

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  10 in total

1.  Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent.

Authors:  V V Ogryzko; T H Hirai; V R Russanova; D A Barbie; B H Howard
Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

2.  New sites of methylcytosine-rich DNA detected on metaphase chromosomes.

Authors:  A Barbin; C Montpellier; N Kokalj-Vokac; A Gibaud; A Niveleau; B Malfoy; B Dutrillaux; C A Bourgeois
Journal:  Hum Genet       Date:  1994-12       Impact factor: 4.132

3.  Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon.

Authors:  Julia Sauer; Hyeran Jang; Ella M Zimmerly; Kyong-Chol Kim; Zhenhua Liu; Aurelie Chanson; Donald E Smith; Joel B Mason; Simonetta Friso; Sang-Woon Choi
Journal:  Br J Nutr       Date:  2010-03-08       Impact factor: 3.718

4.  Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue.

Authors:  Agate Noer; Anita L Sørensen; Andrew C Boquest; Philippe Collas
Journal:  Mol Biol Cell       Date:  2006-06-07       Impact factor: 4.138

5.  Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

Authors:  Q Chen; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

6.  Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.

Authors:  Jonathan D Wren; Harold R Garner
Journal:  J Biomed Biotechnol       Date:  2005-06-30

Review 7.  Why are human cells resistant to malignant cell transformation in vitro?

Authors:  T Kuroki; N H Huh
Journal:  Jpn J Cancer Res       Date:  1993-11

8.  m5Cpred-XS: A New Method for Predicting RNA m5C Sites Based on XGBoost and SHAP.

Authors:  Yinbo Liu; Yingying Shen; Hong Wang; Yong Zhang; Xiaolei Zhu
Journal:  Front Genet       Date:  2022-03-30       Impact factor: 4.599

Review 9.  The Impact of External Factors on the Epigenome: In Utero and over Lifetime.

Authors:  Estela G Toraño; María G García; Juan Luis Fernández-Morera; Pilar Niño-García; Agustín F Fernández
Journal:  Biomed Res Int       Date:  2016-05-18       Impact factor: 3.411

10.  Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers.

Authors:  Yuting He; Xiao Yu; Menggang Zhang; Wenzhi Guo
Journal:  World J Surg Oncol       Date:  2021-07-29       Impact factor: 2.754
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.