Literature DB >> 17219235

Restricted diffusion in Canavan disease.

S G Srikanth1, H S Chandrashekar, K Nagarajan, P N Jayakumar.   

Abstract

INTRODUCTION: Canavan disease is a megalencephalic leukodystrophy due to deficiency of the enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-L: -aspartate is considered diagnostic of Canavan disease. CASE REPORT: We report a case of Canavan disease, which showed restricted diffusion in diffusion-weighted imaging and discuss the cause of it.

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Year:  2007        PMID： 17219235     DOI： 10.1007/s00381-006-0238-9

Source DB:  PubMed          Journal:  Childs Nerv Syst        ISSN： 0256-7040            Impact factor:   1.475


  14 in total

Review 1.  Prenatal diagnosis of Canavan disease.

Authors:  R Matalon; K Michals-Matalon
Journal:  Prenat Diagn       Date:  1999-07       Impact factor: 3.050

Review 2.  Canavan disease prenatal diagnosis and genetic counseling.

Authors:  Reuben Matalon; Kimberlee Michals Matalon
Journal:  Obstet Gynecol Clin North Am       Date:  2002-06       Impact factor: 2.844

3.  Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.

Authors:  Batool F Kirmani; David M Jacobowitz; Abraham T Kallarakal; M A A Namboodiri
Journal:  Brain Res Mol Brain Res       Date:  2002-11-15

4.  Spongy degeneration of the central nervous system (van Bogaert-Bertrand type?) in a newborn infant. A light and electron microscopic study.

Authors:  J Towfighi; Z Friedman; M J Maisels
Journal:  Acta Neuropathol       Date:  1977-03-31       Impact factor: 17.088

Review 5.  Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review.

Authors:  Morris H Baslow
Journal:  Neurochem Int       Date:  2002-04       Impact factor: 3.921

6.  Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease.

Authors:  R Matalon; K Michals; D Sebesta; M Deanching; P Gashkoff; J Casanova
Journal:  Am J Med Genet       Date:  1988-02

7.  Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease.

Authors:  Chikkathur N Madhavarao; Peethambaran Arun; John R Moffett; Sylvia Szucs; Sankar Surendran; Reuben Matalon; James Garbern; Diana Hristova; Anne Johnson; Wei Jiang; M A Aryan Namboodiri
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-22       Impact factor: 11.205

8.  Diffusion magnetic resonance imaging patterns in metabolic and toxic brain disorders.

Authors:  R N Sener
Journal:  Acta Radiol       Date:  2004-08       Impact factor: 1.990

9.  In vivo assessment of N-acetylaspartate in brain in spongy degeneration (Canavan's disease) by proton spectroscopy.

Authors:  W Grodd; I Krägeloh-Mann; D Petersen; F K Trefz; K Harzer
Journal:  Lancet       Date:  1990-08-18       Impact factor: 79.321

Review 10.  Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation.

Authors:  Morris H Baslow
Journal:  J Mol Neurosci       Date:  2003       Impact factor: 3.444
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  5 in total

1.  Molecular characterisation and prenatal diagnosis of Asparto-acylase deficiency (Canavan disease)--report of two novel and two known mutations from the Indian subcontinent.

Authors:  Sunita Bijarnia; Sudha Kohli; Ratna Dua Puri; Rintu J Jacob; Renu Saxena; Anil Jalan; Eric A Sistermans; Saqib Mahmood; Ishwar Chander Verma
Journal:  Indian J Pediatr       Date:  2012-08-10       Impact factor: 1.967

2.  N-acetylaspartic acid impairs enzymatic antioxidant defenses and enhances hydrogen peroxide concentration in rat brain.

Authors:  Carolina Didonet Pederzolli; Caroline Paula Mescka; Alessandra Selinger Magnusson; Kátia Bueno Deckmann; Evelise de Souza Streck; Angela Malysz Sgaravatti; Mirian Bonaldi Sgarbi; Angela T S Wyse; Clovis M D Wannmacher; Moacir Wajner; Carlos S Dutra-Filho
Journal:  Metab Brain Dis       Date:  2010-05-01       Impact factor: 3.584

3.  Neuroprotective role of lipoic acid against acute toxicity of N-acetylaspartic acid.

Authors:  Carolina Didonet Pederzolli; Andrea Pereira Rosa; Amanda Szekir de Oliveira; Juliana G Coelho; Débora da Luz Becker; Giovana Reche Dalazen; Tarsila Barros Moraes; Carlos S Dutra-Filho
Journal:  Mol Cell Biochem       Date:  2010-08-05       Impact factor: 3.396

4.  Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats.

Authors:  Carolina Didonet Pederzolli; Francieli Juliana Rockenbach; Fernanda Rech Zanin; Nicoli Taiana Henn; Eline Coan Romagna; Angela M Sgaravatti; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Angela de Mattos Dutra; Carlos S Dutra-Filho
Journal:  Metab Brain Dis       Date:  2009-03-18       Impact factor: 3.584

Review 5.  In Vivo NMR Studies of the Brain with Hereditary or Acquired Metabolic Disorders.

Authors:  Erica B Sherry; Phil Lee; In-Young Choi
Journal:  Neurochem Res       Date:  2015-11-26       Impact factor: 3.996
  5 in total

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