| Literature DB >> 17219018 |
A K Cheung1, K M Lager, O I Kohutyuk, A L Vincent, S C Henry, R B Baker, R R Rowland, A G Dunham.
Abstract
In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.Entities:
Mesh：
Year: 2007 PMID： 17219018 PMCID： PMC7086833 DOI： 10.1007/s00705-006-0909-6
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574