Literature DB >> 172188

Regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in type II hyperlipoproteinaemia.

D J Betteridge, M J Higgins, D J Galton.   

Abstract

The regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in leucocytes was studied in a family with familial type II hyperlipoproteinaemia (WHO classification). The propositus was heterozygous and 16 other members of the family were studied. Leucocytes were isolated by a relatively quick and simple procedure and used for enzyme estimations. The results suggest that measurement of the regulation of this enzyme in leucocytes may be helpful in the diagnosis and management of the condition.

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Year:  1975        PMID： 172188      PMCID： PMC1675613          DOI： 10.1136/bmj.4.5995.500

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  4 in total

1.  SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.

Authors:  A S COULSON; D G CHALMERS
Journal:  Lancet       Date:  1964-02-29       Impact factor: 79.321

2.  Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.

Authors:  A M Fogelman; J Edmond; J Seager; G Popják
Journal:  J Biol Chem       Date:  1975-03-25       Impact factor: 5.157

3.  Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.

Authors:  J L Goldstein; M S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

4.  Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A.

Authors:  F H Hulcher; W H Oleson
Journal:  J Lipid Res       Date:  1973-11       Impact factor: 5.922
  4 in total
  4 in total

1.  Properties of sterol biosynthesis in human leukocytes: effects of gemfibrozil.

Authors:  D J Betteridge; M J Higgins; D J Galton
Journal:  Proc R Soc Med       Date:  1976

2.  Diagnosing familial hypercholesterolaemia in childhood.

Authors:  J V Leonard; O H Wolfe; J Lloyd; A Whitelaw; J Slack
Journal:  Br Med J       Date:  1977-08-13

3.  Diagnosing familial hypercholesterolaemia in childhood.

Authors:  D J Betteridge; D Galton; M Giggins
Journal:  Br Med J       Date:  1977-07-09

4.  Diagnosing familial hypercholesterolaemia in childhood.

Authors:  D J Galton; D J Betteridge
Journal:  Br Med J       Date:  1977-10-29
  4 in total

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