Literature DB >> 17218510

Comment on "A common genetic variant is associated with adult and childhood obesity".

Dieter Rosskopf1, Alexa Bornhorst, Christian Rimmbach, Christian Schwahn, Alexander Kayser, Anne Krüger, Grietje Tessmann, Ingrid Geissler, Heyo K Kroemer, Henry Völzke.   

Abstract

Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.

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Year:  2007        PMID： 17218510     DOI： 10.1126/science.1130571

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

1.  Multilocus lod scores in large pedigrees: combination of exact and approximate calculations.

Authors:  Liping Tong; Elizabeth Thompson
Journal:  Hum Hered       Date:  2007-10-12       Impact factor: 0.444

2.  Association of the FTO gene with BMI.

Authors:  Steven C Hunt; Steven Stone; Yuanpei Xin; Christina A Scherer; Charles L Magness; Shawn P Iadonato; Paul N Hopkins; Ted D Adams
Journal:  Obesity (Silver Spring)       Date:  2008-01-24       Impact factor: 5.002

Review 3.  Recent progress in the genetics of common obesity.

Authors:  Ruth J F Loos
Journal:  Br J Clin Pharmacol       Date:  2009-12       Impact factor: 4.335

4.  Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.

Authors:  James H Degnan; Jessica Lasky-Su; Benjamin A Raby; Mousheng Xu; Cliona Molony; Eric E Schadt; Christoph Lange
Journal:  Genomics       Date:  2008-06-30       Impact factor: 5.736

5.  On the replication of genetic associations: timing can be everything!

Authors:  Jessica Lasky-Su; Helen N Lyon; Valur Emilsson; Iris M Heid; Cliona Molony; Benjamin A Raby; Ross Lazarus; Barbara Klanderman; Manuel E Soto-Quiros; Lydiana Avila; Edwin K Silverman; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Florian Kronenberg; Caren Vollmert; Thomas Illig; Caroline S Fox; Daniel Levy; Nan Laird; Xiao Ding; Matt B McQueen; Johannah Butler; Kristin Ardlie; Constantina Papoutsakis; George Dedoussis; Christopher J O'Donnell; H-Erich Wichmann; Juan C Celedón; Eric Schadt; Joel Hirschhorn; Scott T Weiss; Kari Stefansson; Christoph Lange
Journal:  Am J Hum Genet       Date:  2008-04       Impact factor: 11.025

Review 6.  From monogenic to polygenic obesity: recent advances.

Authors:  Anke Hinney; Carla I G Vogel; Johannes Hebebrand
Journal:  Eur Child Adolesc Psychiatry       Date:  2010-02-03       Impact factor: 4.785

7.  A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.

Authors:  Ranjan Deka; Ling Xu; Prodipto Pal; Palanitina T Toelupe; Tuiasina S Laumoli; Huifeng Xi; Ge Zhang; Daniel E Weeks; Stephen T McGarvey
Journal:  BMC Med Genet       Date:  2009-12-22       Impact factor: 2.103

8.  The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

Authors:  Jan Bressler; Myriam Fornage; Craig L Hanis; Wen Hong Linda Kao; Cora E Lewis; Ruth McPherson; Robert Dent; Thomas H Mosley; Len A Pennacchio; Eric Boerwinkle
Journal:  BMC Med Genet       Date:  2009-06-12       Impact factor: 2.103

9.  Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

Authors:  Iris M Heid; Cornelia Huth; Ruth J F Loos; Florian Kronenberg; Vera Adamkova; Sonia S Anand; Kristin Ardlie; Heike Biebermann; Peter Bjerregaard; Heiner Boeing; Claude Bouchard; Marina Ciullo; Jackie A Cooper; Dolores Corella; Christian Dina; James C Engert; Eva Fisher; Francesc Francès; Philippe Froguel; Johannes Hebebrand; Robert A Hegele; Anke Hinney; Margret R Hoehe; Frank B Hu; Jaroslav A Hubacek; Steve E Humphries; Steven C Hunt; Thomas Illig; Marjo-Riita Järvelin; Marika Kaakinen; Barbara Kollerits; Heiko Krude; Jitender Kumar; Leslie A Lange; Birgit Langer; Shengxu Li; Andreas Luchner; Helen N Lyon; David Meyre; Karen L Mohlke; Vincent Mooser; Almut Nebel; Thuy Trang Nguyen; Bernhard Paulweber; Louis Perusse; Lu Qi; Tuomo Rankinen; Dieter Rosskopf; Stefan Schreiber; Shantanu Sengupta; Rossella Sorice; Anita Suk; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Henry Völzke; Karani S Vimaleswaran; Nicholas J Wareham; Dawn Waterworth; Salim Yusuf; Cecilia Lindgren; Mark I McCarthy; Christoph Lange; Joel N Hirschhorn; Nan Laird; H-Erich Wichmann
Journal:  PLoS Genet       Date:  2009-10-23       Impact factor: 5.917

10.  Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

Authors:  Susanne Tan; André Scherag; Onno Eilard Janssen; Susanne Hahn; Harald Lahner; Tiina Dietz; Susann Scherag; Harald Grallert; Carla Ivane Ganz Vogel; Rainer Kimmig; Thomas Illig; Klaus Mann; Johannes Hebebrand; Anke Hinney
Journal:  BMC Med Genet       Date:  2010-01-21       Impact factor: 2.103
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