Literature DB >> 17218508

Comment on "A common genetic variant is associated with adult and childhood obesity".

Christian Dina1, David Meyre, Chantal Samson, Jean Tichet, Michel Marre, Beatrice Jouret, Marie Aline Charles, Beverley Balkau, Philippe Froguel.   

Abstract

Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

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Year:  2007        PMID： 17218508     DOI： 10.1126/science.1129402

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  46 in total

1.  Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain.

Authors:  Scott A Kelly; Derrick L Nehrenberg; Kunjie Hua; Theodore Garland; Daniel Pomp
Journal:  Genetics       Date:  2012-03-30       Impact factor: 4.562

2.  Multilocus lod scores in large pedigrees: combination of exact and approximate calculations.

Authors:  Liping Tong; Elizabeth Thompson
Journal:  Hum Hered       Date:  2007-10-12       Impact factor: 0.444

3.  Association of the FTO gene with BMI.

Authors:  Steven C Hunt; Steven Stone; Yuanpei Xin; Christina A Scherer; Charles L Magness; Shawn P Iadonato; Paul N Hopkins; Ted D Adams
Journal:  Obesity (Silver Spring)       Date:  2008-01-24       Impact factor: 5.002

4.  The challenges for molecular nutrition research 1: linking genotype to healthy nutrition.

Authors:  Christine M Williams; Jose M Ordovas; Dennis Lairon; John Hesketh; Georg Lietz; Mike Gibney; Ben van Ommen
Journal:  Genes Nutr       Date:  2008-07       Impact factor: 5.523

Review 5.  Recent progress in the genetics of common obesity.

Authors:  Ruth J F Loos
Journal:  Br J Clin Pharmacol       Date:  2009-12       Impact factor: 4.335

6.  Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.

Authors:  James H Degnan; Jessica Lasky-Su; Benjamin A Raby; Mousheng Xu; Cliona Molony; Eric E Schadt; Christoph Lange
Journal:  Genomics       Date:  2008-06-30       Impact factor: 5.736

7.  On the replication of genetic associations: timing can be everything!

Authors:  Jessica Lasky-Su; Helen N Lyon; Valur Emilsson; Iris M Heid; Cliona Molony; Benjamin A Raby; Ross Lazarus; Barbara Klanderman; Manuel E Soto-Quiros; Lydiana Avila; Edwin K Silverman; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Florian Kronenberg; Caren Vollmert; Thomas Illig; Caroline S Fox; Daniel Levy; Nan Laird; Xiao Ding; Matt B McQueen; Johannah Butler; Kristin Ardlie; Constantina Papoutsakis; George Dedoussis; Christopher J O'Donnell; H-Erich Wichmann; Juan C Celedón; Eric Schadt; Joel Hirschhorn; Scott T Weiss; Kari Stefansson; Christoph Lange
Journal:  Am J Hum Genet       Date:  2008-04       Impact factor: 11.025

8.  Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity.

Authors:  Yvonne Böttcher; Hanne Unbehauen; Nora Klöting; Karen Ruschke; Antje Körner; Dorit Schleinitz; Anke Tönjes; Beate Enigk; Sara Wolf; Kerstin Dietrich; Moritz Koriath; Gerhard Harry Scholz; Yu-Hua Tseng; Arne Dietrich; Michael R Schön; Wieland Kiess; Michael Stumvoll; Matthias Blüher; Peter Kovacs
Journal:  Diabetes       Date:  2009-06-05       Impact factor: 9.461

9.  The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

Authors:  Jan Bressler; Myriam Fornage; Craig L Hanis; Wen Hong Linda Kao; Cora E Lewis; Ruth McPherson; Robert Dent; Thomas H Mosley; Len A Pennacchio; Eric Boerwinkle
Journal:  BMC Med Genet       Date:  2009-06-12       Impact factor: 2.103

10.  Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

Authors:  Iris M Heid; Cornelia Huth; Ruth J F Loos; Florian Kronenberg; Vera Adamkova; Sonia S Anand; Kristin Ardlie; Heike Biebermann; Peter Bjerregaard; Heiner Boeing; Claude Bouchard; Marina Ciullo; Jackie A Cooper; Dolores Corella; Christian Dina; James C Engert; Eva Fisher; Francesc Francès; Philippe Froguel; Johannes Hebebrand; Robert A Hegele; Anke Hinney; Margret R Hoehe; Frank B Hu; Jaroslav A Hubacek; Steve E Humphries; Steven C Hunt; Thomas Illig; Marjo-Riita Järvelin; Marika Kaakinen; Barbara Kollerits; Heiko Krude; Jitender Kumar; Leslie A Lange; Birgit Langer; Shengxu Li; Andreas Luchner; Helen N Lyon; David Meyre; Karen L Mohlke; Vincent Mooser; Almut Nebel; Thuy Trang Nguyen; Bernhard Paulweber; Louis Perusse; Lu Qi; Tuomo Rankinen; Dieter Rosskopf; Stefan Schreiber; Shantanu Sengupta; Rossella Sorice; Anita Suk; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Henry Völzke; Karani S Vimaleswaran; Nicholas J Wareham; Dawn Waterworth; Salim Yusuf; Cecilia Lindgren; Mark I McCarthy; Christoph Lange; Joel N Hirschhorn; Nan Laird; H-Erich Wichmann
Journal:  PLoS Genet       Date:  2009-10-23       Impact factor: 5.917
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