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Literature DB >> 17218252

PTEN enters the nuclear age.

Abstract

Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.

Entities: Disease Gene

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Year: 2007 PMID： 17218252 DOI： 10.1016/j.cell.2006.12.023

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

74 in total

1. PTEN regulates PLK1 and controls chromosomal stability during cell division.

Authors: Zhong Zhang; Sheng-Qi Hou; Jinxue He; Tingting Gu; Yuxin Yin; Wen H Shen
Journal: Cell Cycle Date: 2016-07-11 Impact factor: 4.534

2. Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.

Authors: Atsushi Igarashi; Kie Itoh; Tatsuya Yamada; Yoshihiro Adachi; Takashi Kato; Daisuke Murata; Hiromi Sesaki; Miho Iijima
Journal: J Biol Chem Date: 2018-05-07 Impact factor: 5.157

3. Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.

Authors: Byeong Hyeok Choi; Yan Chen; Wei Dai
Journal: Cell Cycle Date: 2013-09-18 Impact factor: 4.534

4. Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway.

Authors: Li-Qiang Qian; Xia-Qin Li; Peng-Hui Ye; Hao-Yuan Su; Gang Wang; Yan Liu; Gen-Hai Shen; Quan-Gen Gao
Journal: Oncol Lett Date: 2017-08-23 Impact factor: 2.967

5. Immunohistochemical detection of p53, PTEN, Rb, and p16 in canine osteosarcoma using tissue microarray.

Authors: Duncan S Russell; Lauren Jaworski; William C Kisseberth
Journal: J Vet Diagn Invest Date: 2018-04-09 Impact factor: 1.279

6. Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness.

Authors: Pradip De; Yuling Sun; Jennifer H Carlson; Lori S Friedman; Brian R Leyland-Jones; Nandini Dey
Journal: Neoplasia Date: 2014-01 Impact factor: 5.715

PTEN enters the nuclear age.

1. PTEN regulates PLK1 and controls chromosomal stability during cell division.

2. Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.

3. Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.

4. Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway.

5. Immunohistochemical detection of p53, PTEN, Rb, and p16 in canine osteosarcoma using tissue microarray.

6. Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness.

7. Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.

8. Genetic diversity in melanoma metastases from a patient with xeroderma pigmentosum.

Review 9. Regulation and modulation of PTEN activity.

10. CSIG inhibits PTEN translation in replicative senescence.